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    ccmF holocytochrome c synthase CcmF component [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948783, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ccmF
    Official Full Name
    holocytochrome c synthase CcmF component
    Primary source
    ECOCYC:EG12054
    Locus tag
    b2196
    See related
    ASAP:ABE-0007269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2188; yejR
    Summary
    Overexpression causes a decrease in the amount of biofilm formed. [More information is available at EcoGene: EG12054]. CcmF is a membrane protein component of the CcmEFGH holocytochrome c synthetase. [More information is available at EcoCyc: EG12054].
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    Genomic context

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    Sequence:
    NC_000913.3 (2292961..2294904, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator NarP Neighboring gene holocytochrome c synthase CcmH component Neighboring gene thiol:disulfide oxidoreductase CcmG Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein B Neighboring gene cytochrome c maturation protein A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heme ligand identification and redox properties of the cytochrome c synthetase, CcmF. San Francisco B, et al. Biochemistry, 2011 Dec 20. PMID 22066495, Free PMC Article
    2. AtCCMH, an essential component of the c-type cytochrome maturation pathway in Arabidopsis mitochondria, interacts with apocytochrome c. Meyer EH, et al. Proc Natl Acad Sci U S A, 2005 Nov 1. PMID 16236729, Free PMC Article
    3. Probing the heme-binding site of the cytochrome c maturation protein CcmE. Harvat EM, et al. Biochemistry, 2009 Mar 3. PMID 19178152
    4. Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins. Lee JH, et al. Biochim Biophys Acta, 2007 Sep. PMID 17706591
    5. Crystallization and preliminary crystallographic studies of Escherichia coli CcmG/DsbE protein. Ouyang N, et al. Acta Crystallogr D Biol Crystallogr, 2003 Sep. PMID 12925810

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on diphenols and related substances as donors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytochrome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytochrome complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    holocytochrome c synthase CcmF component

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2292961..2294904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416700.1 holocytochrome c synthase CcmF component [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416700.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7KAD5
      Conserved Domains (1) summary
      TIGR00353
      Location:53 → 634
      nrfE; c-type cytochrome biogenesis protein CcmF
    Nucleotide Protein
    Heading Accession and Version

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