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    xdhD fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949079, updated on 3-Dec-2024

    Summary

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    Official Symbol
    xdhD
    Official Full Name
    fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit
    Primary source
    ECOCYC:G7500
    Locus tag
    b2881
    See related
    ASAP:ABE-0009459
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2877; ygfN
    Summary
    XdhD is a xanthine dehydrogenase homolog but probably has no xanthine dehydrogenase activity. [More information is available at EcoGene: EG13064]. A ygfK mutant exhibits a defect in selenate reduction, and it is proposed that YgfK (potential oxidoreductase), YgfM (protein with a FAD domain), and YgfN (molybdopterin protein) are components of a selenate reductase . [More information is available at EcoCyc: G7500].
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    Genomic context

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    Sequence:
    NC_000913.3 (3021316..3024186)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase, Fe-S subunit Neighboring gene putative aminohydrolase SsnA Neighboring gene putative oxidoreductase Neighboring gene xanthine:H(+) symporter XanQ Neighboring gene guanine deaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploring the microbial metalloproteome using MIRAGE. Sevcenco AM, et al. Metallomics, 2011 Dec. PMID 22094925
    2. A genetic analysis of in vivo selenate reduction by Salmonella enterica serovar Typhimurium LT2 and Escherichia coli K12. Guymer D, et al. Arch Microbiol, 2009 Jun. PMID 19415239
    3. Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function. Kozmin SG, et al. Mutat Res, 2007 Jun 1. PMID 17349664, Free PMC Article
    4. Involvement of a putative molybdenum enzyme in the reduction of selenate by Escherichia coli. Bébien M, et al. Microbiology (Reading), 2002 Dec. PMID 12480890
    5. Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage. Xi H, et al. J Bacteriol, 2000 Oct. PMID 10986234, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3021316..3024186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417357.1 fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417357.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9X4C8, A0A8T5YBJ2
      Conserved Domains (1) summary
      TIGR03313
      Location:5 → 955
      Se_sel_red_Mo; probable selenate reductase, molybdenum-binding subunit
    Nucleotide Protein
    Heading Accession and Version

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