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    fadK short chain acyl-CoA synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946213, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fadK
    Official Full Name
    short chain acyl-CoA synthetase
    Primary source
    ECOCYC:EG12357
    Locus tag
    b1701
    See related
    ASAP:ABE-0005676
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1699; ydiD
    Summary
    AFMB Structural Genomics target Number 54 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG12357]. FadK is an acyl-CoA synthetase that is primarily active on short chain fatty acids and acts in anaerobic -oxidation of fatty acids . [More information is available at EcoCyc: EG12357].
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    Genomic context

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    Sequence:
    NC_000913.3 (1782977..1784677)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative electron transfer flavoprotein subunit YdiR Neighboring gene putative electron transfer flavoprotein-quinone oxidoreductase YdiS Neighboring gene ferredoxin-like protein YdiT Neighboring gene phosphoenolpyruvate synthetase Neighboring gene phosphoenolpyruvate synthetase regulatory protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Escherichia coli fadK (ydiD) gene encodes an anerobically regulated short chain acyl-CoA synthetase. Morgan-Kiss RM, et al. J Biol Chem, 2004 Sep 3. PMID 15213221
    2. Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification. Black PN, et al. Microbiol Mol Biol Rev, 2003 Sep. PMID 12966144, Free PMC Article
    3. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Reed JL, et al. Genome Biol, 2003. PMID 12952533, Free PMC Article
    4. Intrinsic and extrinsic approaches for detecting genes in a bacterial genome. Borodovsky M, et al. Nucleic Acids Res, 1994 Nov 11. PMID 7984428, Free PMC Article
    5. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity, forming carbon-sulfur bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid oxidation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    short chain acyl-CoA synthetase
    NP_416216.5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1782977..1784677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416216.5 short chain acyl-CoA synthetase [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5P0J300
      Conserved Domains (1) summary
      PRK06087
      Location:20 → 566
      PRK06087; medium-chain fatty-acid--CoA ligase
    Nucleotide Protein
    Heading Accession and Version

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