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    panZ PanD maturation factor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947963, updated on 3-Dec-2024

    Summary

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    Official Symbol
    panZ
    Official Full Name
    PanD maturation factor
    Primary source
    ECOCYC:EG12211
    Locus tag
    b3459
    See related
    ASAP:ABE-0011296
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3443; livL; panM; yhhK
    Summary
    A strain carrying a deletion of livJ, yhhK and livK is auxotrophic for pantothenate; the auxotrophic phenotype can be complemented by a plasmid carrying the yhhK gene alone. [More information is available at EcoCyc: EG12211].
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    Genomic context

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    Sequence:
    NC_000913.3 (3597984..3598367)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM Neighboring gene branched chain amino acid/phenylalanine ABC transporter membrane subunit LivH Neighboring gene L-leucine/L-phenylalanine ABC transporter periplasmic binding protein Neighboring gene branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein Neighboring gene RNA polymerase sigma factor RpoH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An activator for pyruvoyl-dependent l-aspartate α-decarboxylase is conserved in a small group of the γ-proteobacteria including Escherichia coli. Nozaki S, et al. Microbiologyopen, 2012 Sep. PMID 23170229, Free PMC Article
    2. Linkage map of Escherichia coli K-12, edition 8. Bachmann BJ. Microbiol Rev, 1990 Jun. PMID 2194094, Free PMC Article
    3. The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan). Arnott ZLP, et al. Biochemistry, 2017 Sep 19. PMID 28832133, Free PMC Article
    4. EcoGene: a genome sequence database for Escherichia coli K-12. Rudd KE. Nucleic Acids Res, 2000 Jan 1. PMID 10592181, Free PMC Article
    5. The LIV-I/LS system as a determinant of azaserine sensitivity of Escherichia coli K-12. Koyanagi T, et al. FEMS Microbiol Lett, 2004 Aug 1. PMID 15268940

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acetyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pantothenate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pantothenate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pantothenate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within zymogen activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in zymogen activation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PanD maturation factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3597984..3598367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417916.1 PanD maturation factor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417916.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A828P6B9
      Conserved Domains (1) summary
      NF033213
      Location:1 → 126
      matur_PanM; aspartate 1-decarboxylase autocleavage activator PanM
    Nucleotide Protein
    Heading Accession and Version

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