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    oxyR DNA-binding transcriptional dual regulator OxyR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948462, updated on 3-Dec-2024

    Summary

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    Official Symbol
    oxyR
    Official Full Name
    DNA-binding transcriptional dual regulator OxyR
    Primary source
    ECOCYC:EG10681
    Locus tag
    b3961
    See related
    ASAP:ABE-0012973
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3953; momR; mor
    Summary
    This regulator belongs to the LysR family and participates in controlling several genes involved in the response to oxidative stress and the production of surface proteins that control colony morphology and autoaggregation ability. [More information is available at EcoCyc: EG10681].
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    Genomic context

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    Sequence:
    NC_000913.3 (4158490..4159407)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene argininosuccinate lyase Neighboring gene ncRNA Neighboring gene soluble pyridine nucleotide transhydrogenase Neighboring gene DNA-binding transcriptional repressor FabR Neighboring gene DUF1422 domain-containing inner membrane protein YijD Neighboring gene tRNA m(5)U54 methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of the RNA polymerase alpha subunit C-terminal region in co-operative interaction and transcriptional activation with OxyR protein. Tao K, et al. Mol Microbiol, 1993 Mar. PMID 8483417
    2. Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. Storz G, et al. Science, 1990 Apr 13. PMID 2183352
    3. The OxyR regulon. Storz G, et al. Antonie Van Leeuwenhoek, 1990 Oct. PMID 2256675
    4. OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. Christman MF, et al. Proc Natl Acad Sci U S A, 1989 May. PMID 2471187, Free PMC Article
    5. The Escherichia coli regulatory protein OxyR discriminates between methylated and unmethylated states of the phage Mu mom promoter. Bölker M, et al. EMBO J, 1989 Aug. PMID 2551682, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OxyR Is a Convergent Target for Mutations Acquired during Adaptation to Oxidative Stress-Prone Metabolic States.
      Title: OxyR Is a Convergent Target for Mutations Acquired during Adaptation to Oxidative Stress-Prone Metabolic States.
    2. The authors have determined how ElaB is regulated under oxidative stress: RpoS and OxyR coordinately control the expression of inner membrane protein ElaB.
      Title: Resistance to oxidative stress by inner membrane protein ElaB is regulated by OxyR and RpoS.
    3. Constitutive expression of the OxyR regulon confers the maximum HOCl resistance.
      Title: Evolution of Escherichia coli for maximum HOCl resistance through constitutive expression of the OxyR regulon.
    4. The isogenic oxyR mutant exhibited increased H2O2 sensitivity, indistinguishable in vitro growth, and attenuated virulence in rodent models of urinary tract, subcutaneous infection, and systemic sepsis.
      Title: OxyR contributes to the virulence of a Clonal Group A Escherichia coli strain (O17:K+:H18) in animal models of urinary tract infection, subcutaneous infection, and systemic sepsis.
    5. Oxidative stress response proteins such as AhpF, Dps, and Fur, all of which belong to the oxyR regulon, were upregulated in Escherichia coli isolates from mice fed the lactose-rich diet.
      Title: Impact of nutritional factors on the proteome of intestinal Escherichia coli: induction of OxyR-dependent proteins AhpF and Dps by a lactose-rich diet.
    6. OxyR serves as a master regulator of S-nitrosylation, and alternative posttranslational modifications of OxyR control distinct transcriptional responses
      Title: Endogenous protein S-Nitrosylation in E. coli: regulation by OxyR.
    7. OxyR seems to be a factor stimulating lambda prophage maintenance under conditions of oxidative stress.
      Title: Influence of the Escherichia coli oxyR gene function on lambda prophage maintenance.
    8. Data suggest that the redox state of OxyR and Fnr modulates their interaction with the vgb promoter.
      Title: Redox-mediated interactions of VHb (Vitreoscilla haemoglobin) with OxyR: novel regulation of VHb biosynthesis under oxidative stress.
    9. The data support a model in which in an ON-phase cell, the subcellular OxyR availability at the replication fork as it passes through the agn43 regulatory region is key for initiating an ON-to-OFF switch.
      Title: Establishing and maintaining sequestration of Dam target sites for phase variation of agn43 in Escherichia coli.
    10. deletion mutant strains fail to enhance oxidative stress resistance following treatment with tannin and quercetin
      Title: Influence of polyphenols on Escherichia coli resistance to oxidative stress.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nitrosative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator OxyR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4158490..4159407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418396.1 DNA-binding transcriptional dual regulator OxyR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418396.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6P981, A0A6N0IJR7
      Conserved Domains (1) summary
      PRK11151
      Location:1 → 305
      PRK11151; DNA-binding transcriptional regulator OxyR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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