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    mdtH multidrug efflux pump MdtH [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946920, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mdtH
    Official Full Name
    multidrug efflux pump MdtH
    Primary source
    ECOCYC:G6559
    Locus tag
    b1065
    See related
    ASAP:ABE-0003618
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1050; yceL
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG13878]. The YceL protein is, based on sequence similarity and hydropathy analysis, a member of the major facilitator superfamily (MFS) . [More information is available at EcoCyc: G6559].
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    Genomic context

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    Sequence:
    NC_000913.3 (1124118..1125326, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipid-binding lipoprotein YceB Neighboring gene reduced glutaredoxin 2 Neighboring gene ribosomal-protein-S5-alanine N-acetyltransferase Neighboring gene DUF480 domain-containing protein YceH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, overexpression, and characterization of glutaredoxin 2, an atypical glutaredoxin from Escherichia coli. Vlamis-Gardikas A, et al. J Biol Chem, 1997 Apr 25. PMID 9111025
    2. Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes. Paulsen IT, et al. J Mol Biol, 2000 Aug 4. PMID 10926494
    3. Indole induces the expression of multidrug exporter genes in Escherichia coli. Hirakawa H, et al. Mol Microbiol, 2005 Feb. PMID 15686558
    4. Analysis of a complete library of putative drug transporter genes in Escherichia coli. Nishino K, et al. J Bacteriol, 2001 Oct. PMID 11566977, Free PMC Article
    5. Genome-wide screening of genes affecting glycogen metabolism in Escherichia coli K-12. Eydallin G, et al. FEBS Lett, 2007 Jun 26. PMID 17543954

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multidrug efflux pump MdtH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1124118..1125326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415583.4 multidrug efflux pump MdtH [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415583.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L5H8P4
      Conserved Domains (1) summary
      PRK11646
      Location:1 → 400
      PRK11646; multidrug efflux MFS transporter MdtH
    Nucleotide Protein
    Heading Accession and Version

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