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    hisJ histidine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945309, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hisJ
    Official Full Name
    histidine ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:EG12124
    Locus tag
    b2309
    See related
    ASAP:ABE-0007617
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2303
    Summary
    Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG12124]. HisPMQJ is an ATP-dependent histidine transport system that is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG12124].
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    Genomic context

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    Sequence:
    NC_000913.3 (2426006..2426788, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, ATP binding subunit Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisQ Neighboring gene lysine/arginine/ornithine ABC transporter periplasmic binding protein Neighboring gene flavin prenyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Backbone resonance assignments for the ligand binding subunit of the histidine permease complex (HisJ) from Escherichia coli, under histidine-bound and unbound states. Igarashi S, et al. Biomol NMR Assign, 2010 Apr. PMID 19921465
    2. Crystallization and preliminary X-ray crystallographic data of a histidine-binding protein from Escherichia coli. Trakhanov SD, et al. J Mol Biol, 1989 Jun 20. PMID 2668541
    3. The histidine-binding protein J, a histidine transport component, has two different functional sites. Kustu SG, et al. J Biol Chem, 1974 Nov 10. PMID 4213931
    4. Refined 1.89-A structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport/chemosensory proteins. Yao N, et al. Biochemistry, 1994 Apr 26. PMID 8161536
    5. Ligand binding specificity of the Escherichia coli periplasmic histidine binding protein, HisJ. Paul S, et al. Protein Sci, 2017 Feb. PMID 27865021, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables amino acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-histidine import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histidine ABC transporter periplasmic binding protein
    NP_416812.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2426006..2426788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416812.1 histidine ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416812.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FYU1, A0A8S7I920
      Conserved Domains (1) summary
      PRK15437
      Location:1 → 259
      PRK15437; histidine ABC transporter substrate-binding protein HisJ; Provisional
    Nucleotide Protein
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