Gpr135 G protein-coupled receptor 135 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr135provided by RGD
Official Full Name: G protein-coupled receptor 135provided by RGD
Primary source: RGD:727844
See related: EnsemblRapid:ENSRNOG00000004499 AllianceGenome:RGD:727844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity and arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human GPR135 (G protein-coupled receptor 135). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (96363466..96366594, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (90627533..90630661, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (94816976..94818349, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we conclude that the orphan receptor GPR135 is expressed in different tissues and its expression tends to be modified due to diabetes, besides that it is functional and that it seems to be coupled to Gi/o protein which has negative chronotropic and inotropic effects, therefore, we do not rule out that it participates in the cardiovascular complications associated with diabetes.
Title: Altered function and expression of the orphan GPR135 at the cardiovascular level in diabetic Wistar rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor 135

Names: probable G-protein coupled receptor 135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181771.2 → NP_861436.1 G-protein coupled receptor 135

See identical proteins and their annotated locations for NP_861436.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q7TQN7

UniProtKB/TrEMBL

A6HC28

Related

ENSRNOP00000005933.2, ENSRNOT00000005933.4

Conserved Domains (2) summary

cd14964
Location:107 → 132

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:89 → 361

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily