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    fmt 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947779, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fmt
    Official Full Name
    10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase
    Primary source
    ECOCYC:EG11268
    Locus tag
    b3288
    See related
    ASAP:ABE-0010781
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3274; ftm; yhdD
    Summary
    The fmt gene encodes 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase . [More information is available at EcoCyc: EG11268].
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    Genomic context

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    Sequence:
    NC_000913.3 (3434214..3435161)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF494 domain-containing protein Smg Neighboring gene protein Smf Neighboring gene peptide deformylase Neighboring gene 16S rRNA m(5)C967 methyltransferase Neighboring gene NAD-binding component of Trk potassium transporters

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Initiating translation with D-amino acids. Goto Y, et al. RNA, 2008 Jul. PMID 18515548, Free PMC Article
    2. Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase. Lee CP, et al. Proc Natl Acad Sci U S A, 1992 Oct 1. PMID 1409632, Free PMC Article
    3. The level of Fmt-tRNA on ribosomes from streptomycin treated cells. Lennette ET, et al. Biochem Biophys Res Commun, 1970 Nov 9. PMID 4920879
    4. Methionyl soluble ribonucleic acid transformylase. I. Purification and partial characterization. Dickerman HW, et al. J Biol Chem, 1967 Apr 10. PMID 5337045
    5. Transfer RNA labeling of Escherichia coli methionyl-tRNA transformylase. Hountondji C, et al. Eur J Biochem, 1980 Jun. PMID 6995120

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionyl-tRNA formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionyl-tRNA formyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methionyl-tRNA formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within charged-tRNA amino acid modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in charged-tRNA amino acid modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase
    NP_417746.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3434214..3435161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417746.1 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417746.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3R0MXX4
      Conserved Domains (1) summary
      PRK00005
      Location:5 → 314
      fmt; methionyl-tRNA formyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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