Cobl cordon-bleu WH2 repeat protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coblprovided by RGD
Official Full Name: cordon-bleu WH2 repeat proteinprovided by RGD
Primary source: RGD:1312002
See related: EnsemblRapid:ENSRNOG00000004281 AllianceGenome:RGD:1312002
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin monomer binding activity. Predicted to be involved in several processes, including actin filament organization; embryonic pattern specification; and positive regulation of cell projection organization. Predicted to act upstream of or within actin cytoskeleton organization and neural tube closure. Located in cell cortex and plasma membrane. Orthologous to human COBL (cordon-bleu WH2 repeat protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 56.4), Liver (RPKM 52.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (91041721..91274272, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (86828137..87060682, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (92341949..92497169, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
Title: Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
Cobl is an actin nucleator controlling neuronal morphology and development.
Title: Cordon-bleu is an actin nucleation factor and controls neuronal morphology.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130337 (e-PCR)
- UniSTS:213621

BE120256 (e-PCR)
- UniSTS:247279

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament network formation	IEA Inferred from Electronic Annotation more info
involved_in actin filament network formation	ISO Inferred from Sequence Orthology more info
involved_in actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in collateral sprouting in absence of injury	IEA Inferred from Electronic Annotation more info
involved_in collateral sprouting in absence of injury	ISO Inferred from Sequence Orthology more info
involved_in digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in embryonic axis specification	IEA Inferred from Electronic Annotation more info
involved_in embryonic axis specification	ISO Inferred from Sequence Orthology more info
involved_in floor plate development	IEA Inferred from Electronic Annotation more info
involved_in floor plate development	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in notochord development	IEA Inferred from Electronic Annotation more info
involved_in notochord development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in somite specification	IEA Inferred from Electronic Annotation more info
involved_in somite specification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axonal growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in axonal growth cone	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendritic growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic growth cone	IEA Inferred from Electronic Annotation more info
located_in dendritic growth cone	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
is_active_in terminal web	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal web	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein cordon-bleu

Names: cordon-bleu homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401101.1 → NP_001388030.1 protein cordon-bleu isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A0G2K2Q1, A0A8I6AEB0

Related

ENSRNOP00000097856.2, ENSRNOT00000105473.2
NM_001401102.1 → NP_001388031.1 protein cordon-bleu isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6AEB0, A0A8I6ASN2

Related

ENSRNOP00000107957.1, ENSRNOT00000135785.1
NM_001401103.1 → NP_001388032.1 protein cordon-bleu isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6AEB0

Related

ENSRNOP00000091350.2, ENSRNOT00000110506.2
NM_001401104.1 → NP_001388033.1 protein cordon-bleu isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6AEB0
NM_001401105.1 → NP_001388034.1 protein cordon-bleu isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I5ZV00, A0A8I6AEB0

Related

ENSRNOP00000063258.2, ENSRNOT00000064483.3
NM_001401106.1 → NP_001388035.1 protein cordon-bleu isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6AEB0
NM_001401108.1 → NP_001388037.1 protein cordon-bleu isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6AJQ5

Related

ENSRNOP00000102446.1, ENSRNOT00000141519.1
NM_001401109.1 → NP_001388038.1 protein cordon-bleu isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6AJQ5
NM_001401112.1 → NP_001388041.1 protein cordon-bleu isoform 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6AJQ5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

91041721..91274272 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092058.2 → XP_038947986.1 protein cordon-bleu isoform X8

UniProtKB/TrEMBL

A0A8I6AEB0

Conserved Domains (4) summary

pfam09469
Location:152 → 228

Cobl; Cordon-bleu ubiquitin-like domain

cd21799
Location:1170 → 1202

WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins

cd21800
Location:1216 → 1256

WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins

cd21801
Location:1304 → 1329

WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins
XM_039092060.2 → XP_038947988.1 protein cordon-bleu isoform X9

UniProtKB/TrEMBL

A0A8I6AEB0

Conserved Domains (4) summary

pfam09469
Location:152 → 228

Cobl; Cordon-bleu ubiquitin-like domain

cd21799
Location:1138 → 1170

WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins

cd21800
Location:1184 → 1224

WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins

cd21801
Location:1272 → 1297

WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins
XM_039092053.2 → XP_038947981.1 protein cordon-bleu isoform X5

UniProtKB/TrEMBL

A0A8I6AEB0

Conserved Domains (4) summary

pfam09469
Location:152 → 228

Cobl; Cordon-bleu ubiquitin-like domain

cd21799
Location:1195 → 1227

WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins

cd21800
Location:1241 → 1281

WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins

cd21801
Location:1329 → 1354

WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins
XM_063273232.1 → XP_063129302.1 protein cordon-bleu isoform X10

UniProtKB/TrEMBL

A0A8I6AEB0
XM_063273227.1 → XP_063129297.1 protein cordon-bleu isoform X1

UniProtKB/TrEMBL

A0A8I6AEB0

Related

ENSRNOP00000072330.3, ENSRNOT00000086154.3
XM_063273229.1 → XP_063129299.1 protein cordon-bleu isoform X4

UniProtKB/TrEMBL

A0A8I6AEB0
XM_063273230.1 → XP_063129300.1 protein cordon-bleu isoform X6

UniProtKB/TrEMBL

A0A8I6AEB0
XM_063273231.1 → XP_063129301.1 protein cordon-bleu isoform X7

UniProtKB/TrEMBL

A0A8I6AEB0
XM_039092055.2 → XP_038947983.2 protein cordon-bleu isoform X3

UniProtKB/TrEMBL

A0A8I6AEB0
XM_063273228.1 → XP_063129298.1 protein cordon-bleu isoform X2

UniProtKB/TrEMBL

A0A8I6AEB0

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107236.1: Suppressed sequence

Description

NM_001107236.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.