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    nikD Ni(2(+)) ABC transporter ATP binding subunit NikD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947989, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nikD
    Official Full Name
    Ni(2(+)) ABC transporter ATP binding subunit NikD
    Primary source
    ECOCYC:EG12078
    Locus tag
    b3479
    See related
    ASAP:ABE-0011360
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3463; hydC; hydD
    Summary
    Mutants display nickel-remediated formate hydrogen-lyase, hydrogenase, and hydrogenase-related fumarase defects. [More information is available at EcoGene: EG12078]. The NikABCDE ATP-dependent nickel (II) uptake system is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG12078].
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    Genomic context

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    Sequence:
    NC_000913.3 (3617015..3617779)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Ni(2(+)) ABC transporter periplasmic binding protein Neighboring gene Ni(2(+)) ABC transporter membrane subunit NikB Neighboring gene Ni(2(+)) ABC transporter membrane subunit NikC Neighboring gene Ni(2(+)) ABC transporter ATP binding subunit NikE Neighboring gene DNA-binding transcriptional repressor NikR Neighboring gene rhs element protein RhsB Neighboring gene PF15631 family protein YhhH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Ni-(L-His)₂ as a substrate for NikABCDE-dependent nickel uptake in Escherichia coli. Chivers PT, et al. Metallomics, 2012 Oct. PMID 22885853
    2. The hydC region contains a multi-cistronic operon (nik) involved in nickel transport in Escherichia coli. Wu LF, et al. Gene, 1991 Oct 30. PMID 1743519
    3. Purification and characterization of the periplasmic nickel-binding protein NikA of Escherichia coli K12. de Pina K, et al. Eur J Biochem, 1995 Feb 1. PMID 7867647
    4. Crystallographic and spectroscopic evidence for high affinity binding of FeEDTA(H2O)- to the periplasmic nickel transporter NikA. Cherrier MV, et al. J Am Chem Soc, 2005 Jul 20. PMID 16011372
    5. Complex transcriptional control links NikABCDE-dependent nickel transport with hydrogenase expression in Escherichia coli. Rowe JL, et al. J Bacteriol, 2005 Sep. PMID 16159764, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type nickel transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nickel cation import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nickel cation import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nickel cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligopeptide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ni(2(+)) ABC transporter ATP binding subunit NikD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3617015..3617779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417936.1 Ni(2(+)) ABC transporter ATP binding subunit NikD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417936.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GBF1, A0A5B9AMY4
      Conserved Domains (1) summary
      PRK10418
      Location:1 → 254
      nikD; nickel transporter ATP-binding protein NikD; Provisional
    Nucleotide Protein
    Heading Accession and Version

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