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    ATP11A ATPase phospholipid transporting 11A [ Homo sapiens (human) ]

    Gene ID: 23250, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ATP11Aprovided by HGNC
    Official Full Name
    ATPase phospholipid transporting 11Aprovided by HGNC
    Primary source
    HGNC:HGNC:13552
    See related
    Ensembl:ENSG00000068650 MIM:605868; AllianceGenome:HGNC:13552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATPIH; ATPIS; AUNA2; HLD24; DFNA84
    Summary
    The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. [provided by RefSeq, Apr 2022]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Broad expression in lung (RPKM 20.5), gall bladder (RPKM 8.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ATP11A in Genome Data Viewer
    Location:
    13q34
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (112690038..112887168)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (111938073..112137143)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113344352..113541482)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113302064-113302958 Neighboring gene Sharpr-MPRA regulatory region 9322 Neighboring gene ATP11A upstream neighbor lncRNA Neighboring gene uncharacterized LOC102725228 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113343189-113343706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5535 Neighboring gene NANOG hESC enhancer GRCh37_chr13:113346005-113346506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113356801-113357507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113358129-113358672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113368127-113368956 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:113373763-113374962 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:113377535-113378036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113378763-113379342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113379343-113379922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113383173-113383972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113385574-113386373 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113387175-113387973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113388912-113389644 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113388178-113388911 Neighboring gene Sharpr-MPRA regulatory region 8271 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:113391352-113391852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:113391853-113392353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113400527-113401048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113401693-113402192 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:113409322-113410521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113411061-113411619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113410501-113411060 Neighboring gene ATP11A antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113416805-113417352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113417353-113417898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113418783-113419766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113419767-113420748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8033 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113424987-113425542 Neighboring gene uncharacterized LOC124903253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113430716-113431329 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113432945-113433094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113434144-113435009 Neighboring gene uncharacterized LOC124903252 Neighboring gene NANOG hESC enhancer GRCh37_chr13:113444396-113445115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113460948-113461629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113462993-113463672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113505150-113505650 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:113526644-113527843 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113529546-113529735 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113533651 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113534907 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113536132 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113537448 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113539894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113540393-113540968 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 13:113543499 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113546091-113546840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113552283-113552788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113556232-113557108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113557109-113557983 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113559740-113560614 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113560615-113561488 Neighboring gene uncharacterized LOC124903214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113583655-113584497 Neighboring gene MCF.2 cell line derived transforming sequence like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5536 Neighboring gene Sharpr-MPRA regulatory region 2656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113607452-113608169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113610492-113611232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113611233-113611972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113611973-113612713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113615435-113616158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113617605-113618326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113622683-113623202 Neighboring gene MCF2L antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Disease Mutation Study Identifies Critical Residues for Phosphatidylserine Flippase ATP11A. Sun K, et al. Biomed Res Int, 2020. PMID 32596364, Free PMC Article
    2. DNA Methylation at ATP11A cg11702988 Is a Biomarker of Lung Disease Severity in Cystic Fibrosis: A Longitudinal Study. Pineau F, et al. Genes (Basel), 2021 Mar 19. PMID 33808877, Free PMC Article
    3. ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer. Miyoshi N, et al. Oncol Rep, 2010 Feb. PMID 20043114
    4. Association of a Single Nucleotide Variant in TERT with Airway Disease in Japanese Rheumatoid Arthritis Patients. Higuchi T, et al. Genes (Basel), 2023 Nov 16. PMID 38003027, Free PMC Article
    5. Autosomal dominant non-syndromic hearing loss maps to DFNA33 (13q34) and co-segregates with splice and frameshift variants in ATP11A, a phospholipid flippase gene. Pater JA, et al. Hum Genet, 2022 Apr. PMID 35278131, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of a Single Nucleotide Variant in TERT with Airway Disease in Japanese Rheumatoid Arthritis Patients.
      Title: Association of a Single Nucleotide Variant in TERT with Airway Disease in Japanese Rheumatoid Arthritis Patients.
    2. A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2.
      Title: A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2.
    3. Autosomal dominant non-syndromic hearing loss maps to DFNA33 (13q34) and co-segregates with splice and frameshift variants in ATP11A, a phospholipid flippase gene.
      Title: Autosomal dominant non-syndromic hearing loss maps to DFNA33 (13q34) and co-segregates with splice and frameshift variants in ATP11A, a phospholipid flippase gene.
    4. A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.
      Title: A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.
    5. DNA Methylation at ATP11A cg11702988 Is a Biomarker of Lung Disease Severity in Cystic Fibrosis: A Longitudinal Study.
      Title: DNA Methylation at ATP11A cg11702988 Is a Biomarker of Lung Disease Severity in Cystic Fibrosis: A Longitudinal Study.
    6. Disease Mutation Study Identifies Critical Residues for Phosphatidylserine Flippase ATP11A.
      Title: Disease Mutation Study Identifies Critical Residues for Phosphatidylserine Flippase ATP11A.
    7. The lipid flippases, ATP8B1 and ATP11A are novel elements of the innate immune response that are essential to attenuate the inflammatory response, possibly by mediating endotoxin-induced internalization of TLR4.
      Title: Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4.
    8. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. ATP11A is a useful predictive marker of metastasis in colorectal cancer patients.
      Title: ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Auditory neuropathy, autosomal dominant 2
    MedGen: C5830542 OMIM: 620384 GeneReviews: Not available
    		not available
    Hearing loss, autosomal dominant 84
    MedGen: C5676952 OMIM: 619810 GeneReviews: Not available
    		Compare labs
    Leukodystrophy, hypomyelinating, 24
    MedGen: C5676974 OMIM: 619851 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine flippase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylethanolamine flippase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylserine flippase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine floppase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane lipid distribution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in lysosomal membrane HDA PubMed 
    located_in membrane HDA PubMed 
    part_of phospholipid-translocating ATPase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phospholipid-translocating ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase IH
    Names
    ATPase, class VI, type 11A
    P4-ATPase flippase complex alpha subunit ATP11A
    phospholipid-translocating ATPase
    potential phospholipid-transporting ATPase IH
    probable phospholipid-transporting ATPase IH
    NP_001392590.1
    NP_001392591.1
    NP_001392592.1
    NP_056020.2
    NP_115565.3
    XP_005268360.1
    XP_005268362.1
    XP_011535782.1
    XP_016875979.1
    XP_016875980.1
    XP_016875981.1
    XP_047286174.1
    XP_047286175.1
    XP_054230292.1
    XP_054230293.1
    XP_054230294.1
    XP_054230295.1
    XP_054230296.1
    XP_054230297.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405661.1 → NP_001392590.1  phospholipid-transporting ATPase IH isoform c

      Status: REVIEWED

      Source sequence(s)
      AL139384, AL356740, AL356752

    2. NM_001405662.1 → NP_001392591.1  phospholipid-transporting ATPase IH isoform d

      Status: REVIEWED

      Source sequence(s)
      AL139384, AL356740, AL356752

    3. NM_001405663.1 → NP_001392592.1  phospholipid-transporting ATPase IH isoform e

      Status: REVIEWED

      Source sequence(s)
      AL139384, AL356740, AL356752

    4. NM_015205.3 → NP_056020.2  phospholipid-transporting ATPase IH isoform a

      See identical proteins and their annotated locations for NP_056020.2

      Status: REVIEWED

      Source sequence(s)
      AB028944, AI703438, AL139384, AL161996, AL356740, AL356752, BC024154, BE675783
      Consensus CDS
      CCDS32011.1
      UniProtKB/Swiss-Prot
      P98196, Q5VXT2
      UniProtKB/TrEMBL
      H0Y547
      Related
      ENSP00000364796.3, ENST00000375645.8
      Conserved Domains (7) summary
      TIGR01652
      Location:45 → 1109
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102 → 187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477 → 585
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:42 → 95
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:851 → 1103
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:639 → 695
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:806 → 849
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    5. NM_032189.4 → NP_115565.3  phospholipid-transporting ATPase IH isoform b

      Status: REVIEWED

      Source sequence(s)
      AB028944, AI703438, AL139384, AL161996, AL356740, AL356752, BC024154, BE675783
      UniProtKB/TrEMBL
      E9PEJ6
      Related
      ENSP00000364781.2, ENST00000375630.6
      Conserved Domains (7) summary
      TIGR01652
      Location:45 → 1109
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102 → 187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477 → 585
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:42 → 95
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:851 → 1103
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:639 → 695
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:806 → 849
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      112690038..112887168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537480.3 → XP_011535782.1  phospholipid-transporting ATPase IH isoform X3

      See identical proteins and their annotated locations for XP_011535782.1

      UniProtKB/TrEMBL
      H0Y547
      Conserved Domains (7) summary
      TIGR01652
      Location:45 → 1110
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102 → 187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477 → 585
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:42 → 95
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:851 → 1103
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:639 → 695
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:806 → 849
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. XM_005268305.5 → XP_005268362.1  phospholipid-transporting ATPase IH isoform X4

      See identical proteins and their annotated locations for XP_005268362.1

      UniProtKB/Swiss-Prot
      P98196, Q5VXT2
      UniProtKB/TrEMBL
      H0Y547
      Related
      ENSP00000420387.1, ENST00000487903.5
      Conserved Domains (7) summary
      TIGR01652
      Location:45 → 1109
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102 → 187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477 → 585
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:42 → 95
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:851 → 1103
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:639 → 695
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:806 → 849
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    3. XM_005268303.5 → XP_005268360.1  phospholipid-transporting ATPase IH isoform X3

      See identical proteins and their annotated locations for XP_005268360.1

      UniProtKB/TrEMBL
      H0Y547
      Conserved Domains (7) summary
      TIGR01652
      Location:45 → 1110
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102 → 187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477 → 585
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:42 → 95
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:851 → 1103
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:639 → 695
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:806 → 849
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    4. XM_017020490.2 → XP_016875979.1  phospholipid-transporting ATPase IH isoform X1

    5. XM_017020491.2 → XP_016875980.1  phospholipid-transporting ATPase IH isoform X2

    6. XM_017020492.2 → XP_016875981.1  phospholipid-transporting ATPase IH isoform X4

      UniProtKB/Swiss-Prot
      P98196, Q5VXT2
      UniProtKB/TrEMBL
      H0Y547
      Conserved Domains (7) summary
      TIGR01652
      Location:45 → 1109
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102 → 187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477 → 585
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:42 → 95
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:851 → 1103
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:639 → 695
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:806 → 849
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    7. XM_047430219.1 → XP_047286175.1  phospholipid-transporting ATPase IH isoform X5

    8. XM_047430218.1 → XP_047286174.1  phospholipid-transporting ATPase IH isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      111938073..112137143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374319.1 → XP_054230294.1  phospholipid-transporting ATPase IH isoform X3

    2. XM_054374321.1 → XP_054230296.1  phospholipid-transporting ATPase IH isoform X4

    3. XM_054374320.1 → XP_054230295.1  phospholipid-transporting ATPase IH isoform X3

    4. XM_054374317.1 → XP_054230292.1  phospholipid-transporting ATPase IH isoform X1

    5. XM_054374318.1 → XP_054230293.1  phospholipid-transporting ATPase IH isoform X2

    6. XM_054374322.1 → XP_054230297.1  phospholipid-transporting ATPase IH isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032210.1: Suppressed sequence

      Description
      NM_032210.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98196.3 GenPept UniProtKB/Swiss-Prot:P98196

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