U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PPHLN1 periphilin 1 [ Homo sapiens (human) ]

    Gene ID: 51535, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PPHLN1provided by HGNC
    Official Full Name
    periphilin 1provided by HGNC
    Primary source
    HGNC:HGNC:19369
    See related
    Ensembl:ENSG00000134283 MIM:608150; AllianceGenome:HGNC:19369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CR; HSPC206; HSPC232
    Summary
    The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 7.4), testis (RPKM 6.2) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PPHLN1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (42326167..42448621)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (42284102..42406479)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (42719969..42842423)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6211 Neighboring gene zinc finger CCHC-type and RNA binding motif containing 1 Neighboring gene microRNA 7851 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:42742996-42743992 Neighboring gene RNA, U6 small nuclear 249, pseudogene Neighboring gene FMR1 autosomal homolog 1 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:42858567-42859766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6214 Neighboring gene prickle planar cell polarity protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6215 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:42875079-42875690 Neighboring gene MPRA-validated peak1687 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4366 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:42877741-42878649 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:42879439-42880178 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:42904440-42905187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:42946987-42947486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4367 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:42984271-42984828 Neighboring gene NANOG hESC enhancer GRCh37_chr12:42996970-42997470 Neighboring gene NANOG hESC enhancer GRCh37_chr12:42997471-42997971 Neighboring gene MPRA-validated peak1688 silencer Neighboring gene long intergenic non-protein coding RNA 2402 Neighboring gene CDGSH iron sulfur domain 1 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a novel locus associated with congenital recessive ichthyosis on 12p11.2-q13. Mizrachi-Koren M, et al. J Invest Dermatol, 2005 Sep. PMID 16117785
    2. Periphilin self-association underpins epigenetic silencing by the HUSH complex. Prigozhin DM, et al. Nucleic Acids Res, 2020 Oct 9. PMID 32976585, Free PMC Article
    3. Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. Kurita M, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474462
    4. Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma. Sia D, et al. Nat Commun, 2015 Jan 22. PMID 25608663
    5. HIV-2/SIV viral protein X counteracts HUSH repressor complex. Chougui G, et al. Nat Microbiol, 2018 Aug. PMID 29891865

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Periphilin self-association underpins epigenetic silencing by the HUSH complex.
      Title: Periphilin self-association underpins epigenetic silencing by the HUSH complex.
    2. The haploid screen identified HUSH, an epigenetic heterochromatin repressor complex composed of three subunits, TASOR, MPP8 and Periphilin. (Review)
      Title: Position-effect variegation revisited: HUSHing up heterochromatin in human cells.
    3. analysis of FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
      Title: Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma.
    4. this study identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphilin; this complex is absent from Drosophila but is conserved from fish to humans.
      Title: GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
    5. Data show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD.
      Title: Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. CR (periphilin) retards S-phase progression by modifying expression of Cdc7 and other genes involved in progression of DNA replication
      Title: Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest.
    8. periphilin is potentially involved in epithelial differentiation and contributes to epidermal integrity and barrier formation
      Title: Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC48786

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in constitutive heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    periphilin-1
    Names
    CDC7 expression repressor
    gastric cancer antigen Ga50

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143787.2 → NP_001137259.1  periphilin-1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.z
      Source sequence(s)
      AC079601, AK129910, BC025306
      Consensus CDS
      CCDS44860.1
      UniProtKB/TrEMBL
      B7Z695
      Related
      ENSP00000393965.2, ENST00000432191.6
      Conserved Domains (2) summary
      pfam11488
      Location:224 → 284
      Lge1; Transcriptional regulatory protein LGE1
      pfam15695
      Location:385 → 420
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113

    2. NM_001143788.2 → NP_001137260.1  periphilin-1 isoform 7

      See identical proteins and their annotated locations for NP_001137260.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon and has multiple differences in the 3' region when compared to variant 1. The resulting isoform (7) has a distinct and shorter C-terminus and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AC079601, AK308022, AY039238, BM995486, CA444170
      Consensus CDS
      CCDS44861.1
      UniProtKB/TrEMBL
      F8W0Q9
      Related
      ENSP00000390681.2, ENST00000449194.6
      Conserved Domains (1) summary
      pfam11488
      Location:260 → 332
      Lge1; Transcriptional regulatory protein LGE1

    3. NM_001143789.2 → NP_001137261.1  periphilin-1 isoform 8

      See identical proteins and their annotated locations for NP_001137261.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two alternate in-frame exons and has multiple differences in the 3' region when compared to variant 1. The resulting isoform (8) has a distinct and shorter C-terminus and lacks two internal segments compared to isoform 1.
      Source sequence(s)
      AC079601, AK129910, AK308022, BM995486, CA444170, DC424443
      UniProtKB/TrEMBL
      F8WF16
      Conserved Domains (1) summary
      pfam11488
      Location:205 → 277
      Lge1; Transcriptional regulatory protein LGE1

    4. NM_001364822.2 → NP_001351751.1  periphilin-1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      F8W0Q9
      Conserved Domains (1) summary
      pfam11488
      Location:267 → 339
      Lge1; Transcriptional regulatory protein LGE1

    5. NM_001364823.2 → NP_001351752.1  periphilin-1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      B7Z695
      Conserved Domains (2) summary
      pfam15695
      Location:392 → 427
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
      pfam11488
      Location:231 → 291
      Lge1; Transcriptional regulatory protein LGE1

    6. NM_001364824.2 → NP_001351753.1  periphilin-1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      F8W0Q9
      Conserved Domains (1) summary
      pfam11488
      Location:223 → 298
      Lge1; Transcriptional regulatory protein LGE1

    7. NM_001364825.2 → NP_001351754.1  periphilin-1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      B7Z695
      Conserved Domains (2) summary
      pfam15695
      Location:360 → 395
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
      pfam11488
      Location:205 → 265
      Lge1; Transcriptional regulatory protein LGE1

    8. NM_001364826.2 → NP_001351755.1  periphilin-1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      Consensus CDS
      CCDS91684.1
      UniProtKB/TrEMBL
      B7Z8M9, F8W6A0
      Related
      ENSP00000256678.8, ENST00000256678.12
      Conserved Domains (2) summary
      pfam15695
      Location:314 → 349
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
      pfam11488
      Location:159 → 219
      Lge1; Transcriptional regulatory protein LGE1

    9. NM_001364827.2 → NP_001351756.1  periphilin-1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      B7Z695
      Conserved Domains (2) summary
      pfam15695
      Location:421 → 456
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
      pfam11488
      Location:260 → 320
      Lge1; Transcriptional regulatory protein LGE1

    10. NM_001364828.2 → NP_001351757.1  periphilin-1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684

    11. NM_001364829.2 → NP_001351758.1  periphilin-1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      B7Z695
      Conserved Domains (2) summary
      pfam15695
      Location:366 → 401
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
      pfam11488
      Location:205 → 265
      Lge1; Transcriptional regulatory protein LGE1

    12. NM_001364830.2 → NP_001351759.1  periphilin-1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684

    13. NM_001364831.2 → NP_001351760.1  periphilin-1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      B7Z695
      Conserved Domains (2) summary
      pfam15695
      Location:373 → 408
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
      pfam11488
      Location:212 → 272
      Lge1; Transcriptional regulatory protein LGE1

    14. NM_001364832.2 → NP_001351761.1  periphilin-1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      F8WF16
      Related
      ENSP00000322048.9, ENST00000317560.13
      Conserved Domains (1) summary
      pfam11488
      Location:212 → 284
      Lge1; Transcriptional regulatory protein LGE1

    15. NM_001364833.2 → NP_001351762.1  periphilin-1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684

    16. NM_001364834.2 → NP_001351763.1  periphilin-1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC079601, AC079684
      UniProtKB/TrEMBL
      F8W0Q9
      Conserved Domains (1) summary
      pfam11488
      Location:267 → 339
      Lge1; Transcriptional regulatory protein LGE1

    17. NM_016488.7 → NP_057572.5  periphilin-1 isoform 1

      See identical proteins and their annotated locations for NP_057572.5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079601, AY039238
      Consensus CDS
      CCDS31777.1
      UniProtKB/Swiss-Prot
      E9PAX8, Q86YT2, Q8IXN3, Q8NEY8, Q8TB09, Q96NB9, Q9NXL4, Q9P0P6, Q9P0R9
      UniProtKB/TrEMBL
      B7Z695
      Related
      ENSP00000378935.2, ENST00000395568.6
      Conserved Domains (2) summary
      pfam11488
      Location:279 → 339
      Lge1; Transcriptional regulatory protein LGE1
      pfam15695
      Location:409 → 444
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113

    18. NM_201438.2 → NP_958846.1  periphilin-1 isoform 5

      See identical proteins and their annotated locations for NP_958846.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences compared to variant 1. The resulting isoform (5) has distinct N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AC079601, AK129910, BC039832
      UniProtKB/Swiss-Prot
      Q8NEY8

    19. NM_201439.2 → NP_958847.1  periphilin-1 isoform 3

      See identical proteins and their annotated locations for NP_958847.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 3' region compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC079601, AK129910, AY157850, CA444170, CF242917
      Consensus CDS
      CCDS8741.1
      UniProtKB/TrEMBL
      F8W0Q9
      Related
      ENSP00000351066.7, ENST00000358314.12
      Conserved Domains (1) summary
      pfam11488
      Location:279 → 351
      Lge1; Transcriptional regulatory protein LGE1

    20. NM_201440.2 → NP_958848.1  periphilin-1 isoform 4

      See identical proteins and their annotated locations for NP_958848.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 1. The resulting isoform (4) has distinct N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AC079601, AK129910, AY157850, CA444170
      Consensus CDS
      CCDS55817.1
      UniProtKB/TrEMBL
      F8W0Q9
      Related
      ENSP00000449331.1, ENST00000552761.5
      Conserved Domains (1) summary
      pfam11488
      Location:231 → 303
      Lge1; Transcriptional regulatory protein LGE1

    21. NM_201515.2 → NP_958923.1  periphilin-1 isoform 2

      See identical proteins and their annotated locations for NP_958923.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region and has multiple differences in the 3' region when compared to variant 1. The resulting isoform (2) has a longer N-terminus and a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC079601, AK129910, CA444170
      Consensus CDS
      CCDS41773.1
      UniProtKB/TrEMBL
      F8W0Q9
      Related
      ENSP00000378947.3, ENST00000395580.7
      Conserved Domains (1) summary
      pfam11488
      Location:286 → 358
      Lge1; Transcriptional regulatory protein LGE1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      42326167..42448621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019434.2 → XP_016874923.1  periphilin-1 isoform X1

    2. XM_011538459.2 → XP_011536761.1  periphilin-1 isoform X4

      See identical proteins and their annotated locations for XP_011536761.1

      UniProtKB/TrEMBL
      B7Z695
      Conserved Domains (2) summary
      pfam11488
      Location:286 → 346
      Lge1; Transcriptional regulatory protein LGE1
      pfam15695
      Location:447 → 482
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113

    3. XM_017019436.2 → XP_016874925.1  periphilin-1 isoform X2

      UniProtKB/TrEMBL
      B7Z695

    4. XM_017019439.1 → XP_016874928.1  periphilin-1 isoform X5

      UniProtKB/TrEMBL
      B7Z695

    5. XM_047428972.1 → XP_047284928.1  periphilin-1 isoform X8

      UniProtKB/TrEMBL
      B7Z695

    6. XM_047428971.1 → XP_047284927.1  periphilin-1 isoform X7

      UniProtKB/TrEMBL
      B7Z695

    7. XM_017019443.1 → XP_016874932.1  periphilin-1 isoform X9

      UniProtKB/TrEMBL
      B7Z695

    8. XM_047428973.1 → XP_047284929.1  periphilin-1 isoform X12

      UniProtKB/TrEMBL
      B7Z695

    9. XM_017019448.2 → XP_016874937.1  periphilin-1 isoform X14

      UniProtKB/TrEMBL
      B7Z695

    10. XM_017019451.2 → XP_016874940.1  periphilin-1 isoform X17

      UniProtKB/TrEMBL
      B7Z695

    11. XM_017019437.3 → XP_016874926.1  periphilin-1 isoform X3

      UniProtKB/TrEMBL
      B7Z695

    12. XM_017019450.2 → XP_016874939.1  periphilin-1 isoform X16

      UniProtKB/TrEMBL
      B7Z695

    13. XM_017019440.2 → XP_016874929.1  periphilin-1 isoform X6

      UniProtKB/TrEMBL
      B7Z695

    14. XM_017019447.2 → XP_016874936.1  periphilin-1 isoform X13

      UniProtKB/TrEMBL
      B7Z695

    15. XM_017019449.2 → XP_016874938.1  periphilin-1 isoform X15

      UniProtKB/TrEMBL
      B7Z695
      Conserved Domains (1) summary
      pfam15695
      Location:366 → 401
      HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113

    16. XM_017019445.3 → XP_016874934.1  periphilin-1 isoform X11

      UniProtKB/TrEMBL
      B7Z695

    17. XM_017019444.3 → XP_016874933.1  periphilin-1 isoform X10

      UniProtKB/TrEMBL
      B7Z695

    18. XM_047428974.1 → XP_047284930.1  periphilin-1 isoform X18

      UniProtKB/TrEMBL
      B7Z8L1

    19. XM_047428975.1 → XP_047284931.1  periphilin-1 isoform X19

      UniProtKB/TrEMBL
      B7Z8L1
      Related
      ENSP00000338510.6, ENST00000337898.10

    20. XM_017019435.2 → XP_016874924.1  periphilin-1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      42284102..42406479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372225.1 → XP_054228200.1  periphilin-1 isoform X4

      UniProtKB/TrEMBL
      B7Z695

    2. XM_054372226.1 → XP_054228201.1  periphilin-1 isoform X5

      UniProtKB/TrEMBL
      B7Z695

    3. XM_054372229.1 → XP_054228204.1  periphilin-1 isoform X8

      UniProtKB/TrEMBL
      B7Z695

    4. XM_054372230.1 → XP_054228205.1  periphilin-1 isoform X9

      UniProtKB/TrEMBL
      B7Z695

    5. XM_054372233.1 → XP_054228208.1  periphilin-1 isoform X12

      UniProtKB/TrEMBL
      B7Z695

    6. XM_054372238.1 → XP_054228213.1  periphilin-1 isoform X17

      UniProtKB/TrEMBL
      B7Z695

    7. XM_054372221.1 → XP_054228196.1  periphilin-1 isoform X1

    8. XM_054372223.1 → XP_054228198.1  periphilin-1 isoform X2

      UniProtKB/TrEMBL
      B7Z695

    9. XM_054372228.1 → XP_054228203.1  periphilin-1 isoform X7

      UniProtKB/TrEMBL
      B7Z695

    10. XM_054372235.1 → XP_054228210.1  periphilin-1 isoform X14

      UniProtKB/TrEMBL
      B7Z695

    11. XM_054372224.1 → XP_054228199.1  periphilin-1 isoform X3

      UniProtKB/TrEMBL
      B7Z695

    12. XM_054372237.1 → XP_054228212.1  periphilin-1 isoform X16

      UniProtKB/TrEMBL
      B7Z695

    13. XM_054372227.1 → XP_054228202.1  periphilin-1 isoform X6

      UniProtKB/TrEMBL
      B7Z695

    14. XM_054372234.1 → XP_054228209.1  periphilin-1 isoform X13

      UniProtKB/TrEMBL
      B7Z695

    15. XM_054372236.1 → XP_054228211.1  periphilin-1 isoform X15

      UniProtKB/TrEMBL
      B7Z695

    16. XM_054372232.1 → XP_054228207.1  periphilin-1 isoform X11

      UniProtKB/TrEMBL
      B7Z695

    17. XM_054372231.1 → XP_054228206.1  periphilin-1 isoform X10

      UniProtKB/TrEMBL
      B7Z695

    18. XM_054372239.1 → XP_054228214.1  periphilin-1 isoform X18

      UniProtKB/TrEMBL
      B7Z8L1

    19. XM_054372240.1 → XP_054228215.1  periphilin-1 isoform X19

      UniProtKB/TrEMBL
      B7Z8L1

    20. XM_054372222.1 → XP_054228197.1  periphilin-1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEY8.2 GenPept UniProtKB/Swiss-Prot:Q8NEY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous