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    tdk thymidine/deoxyuridine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945834, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tdk
    Official Full Name
    thymidine/deoxyuridine kinase
    Primary source
    ECOCYC:EG10994
    Locus tag
    b1238
    See related
    ASAP:ABE-0004157
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1233
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10994]. Early studies of the enzyme indicated that in the presence of an activator or an inhibitor deoxynucleotide the enzyme dimerizes. [More information is available at EcoCyc: EG10994].
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    Genomic context

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    Sequence:
    NC_000913.3 (1293527..1294144)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene DNA-binding transcriptional dual regulator H-NS Neighboring gene pseudo Neighboring gene fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydrogenasealdehyde/alcohol dehydrogenase AdhE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mechanism of mutation induction by a hydrogen bond ambivalent, bicyclic N4-oxy-2'-deoxycytidine in Escherichia coli. Negishi K, et al. Nucleic Acids Res, 1997 Apr 15. PMID 9092660, Free PMC Article
    2. Thymidine kinase from Escherichia coli. Chen MS, et al. Methods Enzymol, 1978. PMID 357898
    3. Nucleotide sequence of the Escherichia coli thymidine kinase gene provides evidence for conservation of functional domains and quaternary structure. Black ME, et al. Mol Microbiol, 1991 Feb. PMID 2041474
    4. Escherichia coli thymidine kinase: nucleotide sequence of the gene and relationships to other thymidine kinases. Bockamp EO, et al. Gene, 1991 May 15. PMID 2060797
    5. A deoxythymidine kinase-deficient mutant of Escherichia coli. I. Isolation and some properties. Hiraga S, et al. Biochim Biophys Acta, 1967 Aug 22. PMID 4228236

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thymidine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thymidine/deoxyuridine kinase
    NP_415754.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1293527..1294144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415754.1 thymidine/deoxyuridine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415754.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1IZ41
      Conserved Domains (1) summary
      PRK04296
      Location:1 → 190
      PRK04296; thymidine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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