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    Mtg2 mitochondrial ribosome-associated GTPase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtg2provided by RGD
    Official Full Name
    mitochondrial ribosome-associated GTPase 2provided by RGD
    Primary source
    RGD:1359243
    See related
    EnsemblRapid:ENSRNOG00000059919 AllianceGenome:RGD:1359243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtpbp5
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in regulation of mitochondrial translation and regulation of respiratory system process. Predicted to be located in mitochondrial inner membrane and mitochondrial ribosome. Orthologous to human MTG2 (mitochondrial ribosome associated GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 83.1), Muscle (RPKM 66.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtg2 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (187543166..187558973)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167165542..167181358)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175448214..175464109)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 7 Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene histamine receptor H3 Neighboring gene oxysterol binding protein-like 2 Neighboring gene uncharacterized LOC120101831

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. Kotani T, et al. Nucleic Acids Res, 2013 Apr 1. PMID 23396448, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of respiratory system process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial ribosome-associated GTPase 2
    Names
    GTP-binding protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013924.2 → NP_001013946.2  mitochondrial ribosome-associated GTPase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AA18, A6KMC2, Q5XIH5
      Related
      ENSRNOP00000088561.1, ENSRNOT00000119776.2

    2. NM_001430335.1 → NP_001417264.1  mitochondrial ribosome-associated GTPase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AA18, A6KMC2, Q5XIH5

    3. NM_001430336.1 → NP_001417265.1  mitochondrial ribosome-associated GTPase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Q5XIH5

    4. NM_001430337.1 → NP_001417266.1  mitochondrial ribosome-associated GTPase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001430338.1 → NP_001417267.1  mitochondrial ribosome-associated GTPase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AA18, A6KMC2, Q5XIH5

    6. NM_001430339.1 → NP_001417268.1  mitochondrial ribosome-associated GTPase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Q5XIH5

    7. NM_001430340.1 → NP_001417269.1  mitochondrial ribosome-associated GTPase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    8. NM_001430341.1 → NP_001417270.1  mitochondrial ribosome-associated GTPase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AA18, A6KMC2, Q5XIH5

    9. NM_001430342.1 → NP_001417271.1  mitochondrial ribosome-associated GTPase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AA18, A6KMC2, Q5XIH5

    10. NM_001430343.1 → NP_001417272.1  mitochondrial ribosome-associated GTPase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    11. NM_001430345.1 → NP_001417274.1  mitochondrial ribosome-associated GTPase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AA18, A6KMC2, Q5XIH5

    12. NM_001430346.1 → NP_001417275.1  mitochondrial ribosome-associated GTPase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    13. NM_001430347.1 → NP_001417276.1  mitochondrial ribosome-associated GTPase 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    14. NM_001430348.1 → NP_001417277.1  mitochondrial ribosome-associated GTPase 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Q5XIH5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      187543166..187558973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283429.1 → XP_063139499.1  mitochondrial ribosome-associated GTPase 2 isoform X1

      UniProtKB/TrEMBL
      Q5XIH5

    2. XM_063283424.1 → XP_063139494.1  mitochondrial ribosome-associated GTPase 2 isoform X1

      UniProtKB/TrEMBL
      Q5XIH5

    3. XM_063283437.1 → XP_063139507.1  mitochondrial ribosome-associated GTPase 2 isoform X5

    4. XM_006235818.5 → XP_006235880.1  mitochondrial ribosome-associated GTPase 2 isoform X1

      Related
      ENSRNOP00000110209.1, ENSRNOT00000172091.1
      Conserved Domains (1) summary
      TIGR02729
      Location:131 → 403
      Obg_CgtA; Obg family GTPase CgtA

    5. XM_063283436.1 → XP_063139506.1  mitochondrial ribosome-associated GTPase 2 isoform X5

    6. XM_063283435.1 → XP_063139505.1  mitochondrial ribosome-associated GTPase 2 isoform X5

    7. XM_063283426.1 → XP_063139496.1  mitochondrial ribosome-associated GTPase 2 isoform X1

      UniProtKB/TrEMBL
      Q5XIH5

    8. XM_063283434.1 → XP_063139504.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    9. XM_063283425.1 → XP_063139495.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    10. XM_063283430.1 → XP_063139500.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      Related
      ENSRNOP00000073234.1, ENSRNOT00000089716.3

    11. XM_063283438.1 → XP_063139508.1  mitochondrial ribosome-associated GTPase 2 isoform X6

    12. XM_063283432.1 → XP_063139502.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      UniProtKB/TrEMBL
      Q5XIH5

    13. XM_006235820.5 → XP_006235882.1  mitochondrial ribosome-associated GTPase 2 isoform X3

      Conserved Domains (1) summary
      TIGR02729
      Location:113 → 385
      Obg_CgtA; Obg family GTPase CgtA

    14. XM_063283427.1 → XP_063139497.1  mitochondrial ribosome-associated GTPase 2 isoform X1

      UniProtKB/TrEMBL
      Q5XIH5

    15. XM_063283439.1 → XP_063139509.1  mitochondrial ribosome-associated GTPase 2 isoform X7

    16. XM_017591618.3 → XP_017447107.1  mitochondrial ribosome-associated GTPase 2 isoform X4

      UniProtKB/TrEMBL
      Q5XIH5

    17. XM_063283431.1 → XP_063139501.1  mitochondrial ribosome-associated GTPase 2 isoform X2

      UniProtKB/TrEMBL
      Q5XIH5

    18. XM_063283433.1 → XP_063139503.1  mitochondrial ribosome-associated GTPase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AA18, A6KMC2, Q5XIH5

    19. XM_063283428.1 → XP_063139498.1  mitochondrial ribosome-associated GTPase 2 isoform X1

      UniProtKB/TrEMBL
      Q5XIH5
    Nucleotide Protein Strain
    Heading Accession and Version

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