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    Ing2 inhibitor of growth family, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290744, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ing2provided by RGD
    Official Full Name
    inhibitor of growth family, member 2provided by RGD
    Primary source
    RGD:1307347
    See related
    EnsemblRapid:ENSRNOG00000013480 AllianceGenome:RGD:1307347
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ing1l
    Summary
    Predicted to enable DNA binding activity; methylated histone binding activity; and phosphatidylinositol binding activity. Predicted to be involved in several processes, including positive regulation of transforming growth factor beta receptor signaling pathway; seminiferous tubule development; and spermatogenesis. Predicted to act upstream of or within negative regulation of apoptotic signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of CCAAT-binding activity factor complex and Sin3-type complex. Predicted to be active in nucleus. Orthologous to human ING2 (inhibitor of growth family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 40.2), Thymus (RPKM 33.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ing2 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (51305311..51316177)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44573592..44584180)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47714756..47725836)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551260 Neighboring gene CDKN2A interacting protein Neighboring gene uncharacterized LOC134482502 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7, pseudogene 1 Neighboring gene ERH, mRNA splicing and mitosis factor, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. Saito M, et al. PLoS One, 2010 Nov 19. PMID 21124965, Free PMC Article
    2. The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. Kaadige MR, et al. J Biol Chem, 2006 Sep 29. PMID 16893883
    3. ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. Sarker KP, et al. J Biol Chem, 2008 May 9. PMID 18334480, Free PMC Article
    4. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Chattopadhyay C, et al. Nucleic Acids Res, 2004. PMID 15243141, Free PMC Article
    5. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male germ-line stem cell asymmetric division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Sin3-type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 2
    Names
    inhibitor of growth family, member 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106083.1 → NP_001099553.1  inhibitor of growth protein 2

      See identical proteins and their annotated locations for NP_001099553.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473995
      UniProtKB/TrEMBL
      A6JPL0, B5DEF8, F7F129
      Conserved Domains (3) summary
      COG5034
      Location:29 → 258
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15683
      Location:212 → 260
      PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
      pfam12998
      Location:26 → 120
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      51305311..51316177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253131.5 → XP_006253193.1  inhibitor of growth protein 2 isoform X1

      Related
      ENSRNOP00000102164.1, ENSRNOT00000166374.1
      Conserved Domains (2) summary
      cd15683
      Location:249 → 297
      PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
      pfam12998
      Location:93 → 157
      ING; Inhibitor of growth proteins N-terminal histone-binding

    2. XM_006253133.5 → XP_006253195.1  inhibitor of growth protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006253195.1

      Conserved Domains (2) summary
      cd15683
      Location:185 → 233
      PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
      pfam12998
      Location:30 → 93
      ING; Inhibitor of growth proteins N-terminal histone-binding

    3. XM_006253132.5 → XP_006253194.1  inhibitor of growth protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006253194.1

      Conserved Domains (2) summary
      cd15683
      Location:185 → 233
      PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
      pfam12998
      Location:30 → 93
      ING; Inhibitor of growth proteins N-terminal histone-binding
    Nucleotide Protein Strain
    Heading Accession and Version

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