fadB multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: fadB
Official Full Name: multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase
Primary source: ECOCYC:EG10279
Locus tag: b3846
See related: ASAP:ABE-0012564
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3838; oldB
Summary: FadR regulon. [More information is available at EcoGene: EG10279]. The alpha subunit has four enzymatic activities associated with it. [More information is available at EcoCyc: EG10279].
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Genomic context

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Sequence:: NC_000913.3 (4028782..4030971, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-terminus verified by Edman degradation on complete protein
Title: Nucleotide sequence of the fadA gene. Primary structure of 3-ketoacyl-coenzyme A thiolase from Escherichia coli and the structural organization of the fadAB operon.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-hydroxyacyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 3-hydroxybutyryl-CoA epimerase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-hydroxybutyryl-CoA epimerase activity	IEA Inferred from Electronic Annotation more info
enables 3-hydroxybutyryl-CoA epimerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IEA Inferred from Electronic Annotation more info
enables enoyl-CoA hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enoyl-CoA hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables enoyl-CoA hydratase activity	IEA Inferred from Electronic Annotation more info
enables enoyl-CoA hydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of fatty acid beta-oxidation multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of fatty acid beta-oxidation multienzyme complex	IEA Inferred from Electronic Annotation more info
part_of fatty acid beta-oxidation multienzyme complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase

NP_418288.1

EC 1.1.1.35

EC 4.2.1.17

EC 5.1.2.3

EC 5.3.3.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

4028782..4030971 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_418288.1 multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_418288.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A8S7EJH1

Conserved Domains (1) summary

PRK11730
Location:1 → 715

fadB; fatty acid oxidation complex subunit alpha FadB