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    N4bp3 Nedd4 binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303112, updated on 9-Dec-2024

    Summary

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    Symbol
    N4bp3provided by RGD
    Full Name
    Nedd4 binding protein 3provided by RGD
    Primary source
    RGD:1308356
    See related
    EnsemblRapid:ENSRNOG00000021731 AllianceGenome:RGD:1308356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308356; C330016o10rik
    Summary
    Predicted to be involved in nervous system development. Predicted to act upstream of with a positive effect on innate immune response. Predicted to be located in axon and dendrite. Predicted to be active in cytoplasmic vesicle. Orthologous to human N4BP3 (NEDD4 binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 54.1), Testes (RPKM 36.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See N4bp3 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36400053..36407609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (35898031..35906704, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (34996702..35005365, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NHP2 ribonucleoprotein Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene uncharacterized LOC102553843 Neighboring gene uncharacterized LOC120095096 Neighboring gene trafficking protein particle complex 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. Schmeisser MJ, et al. Neural Dev, 2013 Sep 17. PMID 24044555, Free PMC Article
    2. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. Murillas R, et al. J Biol Chem, 2002 Jan 25. PMID 11717310
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_positive_effect innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nedd4 binding protein 3
    Names
    NEDD4-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033893.1 → NP_001029065.1  nedd4 binding protein 3

      See identical proteins and their annotated locations for NP_001029065.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ176639
      UniProtKB/Swiss-Prot
      Q3LUD3
      UniProtKB/TrEMBL
      A6HE69
      Conserved Domains (2) summary
      COG1429
      Location:226 → 379
      CobN; Cobalamin biosynthesis protein CobN, Mg-chelatase [Coenzyme transport and metabolism]
      pfam06818
      Location:361 → 519
      Fez1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      36400053..36407609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767681.4 → XP_008765903.1  nedd4 binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_008765903.1

      UniProtKB/Swiss-Prot
      Q3LUD3
      UniProtKB/TrEMBL
      A6HE69
      Related
      ENSRNOP00000030035.2, ENSRNOT00000032386.5
      Conserved Domains (2) summary
      COG1429
      Location:226 → 379
      CobN; Cobalamin biosynthesis protein CobN, Mg-chelatase [Coenzyme transport and metabolism]
      pfam06818
      Location:361 → 519
      Fez1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3LUD3.1 GenPept UniProtKB/Swiss-Prot:Q3LUD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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