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    mlaE intermembrane phospholipid transport system, integral membrane subunit MlaE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947732, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mlaE
    Official Full Name
    intermembrane phospholipid transport system, integral membrane subunit MlaE
    Primary source
    ECOCYC:EG12800
    Locus tag
    b3194
    See related
    ASAP:ABE-0010495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3183; yrbE
    Summary
    YrbE is in an operon with ABC transporter homologs and may be a permease protein. [More information is available at EcoGene: EG12800]. Yrbe is the membrane component of a predicted ABC superfamily toluene efflux transporter. [More information is available at EcoCyc: EG12800].
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    Genomic context

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    Sequence:
    NC_000913.3 (3338466..3339248, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene intermembrane phospholipid transport system protein MlaB Neighboring gene intermembrane phospholipid transport system - periplasmic binding protein Neighboring gene intermembrane phospholipid transport system, substrate binding protein MlaD Neighboring gene intermembrane phospholipid transport system, ATP binding subunit MlaF Neighboring gene putative transport protein YrbG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Tang X, et al. Nat Struct Mol Biol, 2021 Jan. PMID 33199922
    2. Unanticipated functional diversity among the TatA-type components of the Tat protein translocase. Eimer E, et al. Sci Rep, 2018 Jan 22. PMID 29358647, Free PMC Article
    3. Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. Thong S, et al. Elife, 2016 Aug 16. PMID 27529189, Free PMC Article
    4. Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading. Hong M, et al. Infect Immun, 1998 Oct. PMID 9746567, Free PMC Article
    5. Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Zhang N, et al. Proteomics, 2007 Feb. PMID 17309111

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables phospholipid transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intermembrane phospholipid transfer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of phospholipid-translocating ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intermembrane phospholipid transport system, integral membrane subunit MlaE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3338466..3339248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417661.1 intermembrane phospholipid transport system, integral membrane subunit MlaE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417661.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6NPI5
      Conserved Domains (1) summary
      NF033619
      Location:7 → 259
      perm_MlaE_1; lipid asymmetry maintenance ABC transporter permease subunit MlaE
    Nucleotide Protein
    Heading Accession and Version

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