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    ftsE cell division protein FtsE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947968, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ftsE
    Official Full Name
    cell division protein FtsE
    Primary source
    ECOCYC:EG10340
    Locus tag
    b3463
    See related
    ASAP:ABE-0011313
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3447
    Summary
    Divisome, non-essential. [More information is available at EcoGene: EG10340]. FtsE is the putative ATP-binding protein component of an ATP-binding cassette (ABC) transporter. [More information is available at EcoCyc: EG10340].
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    Genomic context

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    Sequence:
    NC_000913.3 (3602079..3602747, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein Neighboring gene RNA polymerase sigma factor RpoH Neighboring gene cell division protein FtsX Neighboring gene signal recognition particle receptor Neighboring gene 16S rRNA m(2)G966 methyltransferase Neighboring gene DUF1145 domain-containing protein YhhL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localised mutagenesis of the fts YEX operon: conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia coli are similar to those found in the cystic fibrosis transmembrane conductance regulator protein (CFTR) of human patients. Gibbs TW, et al. Mol Gen Genet, 1992 Jul. PMID 1379670
    2. Interaction between cell division proteins FtsE and FtsZ. Corbin BD, et al. J Bacteriol, 2007 Apr. PMID 17307852, Free PMC Article
    3. Genetic analysis of essential genes in the ftsE region of the Escherichia coli genetic map and identification of a new cell division gene, ftsS. Salmond GP, et al. Mol Gen Genet, 1984. PMID 6394955
    4. Division behavior and shape changes in isogenic ftsZ, ftsQ, ftsA, pbpB, and ftsE cell division mutants of Escherichia coli during temperature shift experiments. Taschner PE, et al. J Bacteriol, 1988 Apr. PMID 3280547, Free PMC Article
    5. FtsEX acts on FtsA to regulate divisome assembly and activity. Du S, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27503875, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
      Title: Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
    2. FtsEX first interacts with FtsZ to localize to the Z ring and then interacts with FtsA to promote divisome assembly and regulate septal peptidoglycan synthesis.
      Title: How FtsEX localizes to the Z ring and interacts with FtsA to regulate cell division.
    3. FtsEX acts on FtsA to regulate both divisome assembly and activity.
      Title: FtsEX acts on FtsA to regulate divisome assembly and activity.
    4. FtsE uses ATP to facilitate constriction rather than assembly of the septal ring.
      Title: ATP-binding site lesions in FtsE impair cell division.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in division septum assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidoglycan turnover NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell division site NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of divisome complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of plasma membrane protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division protein FtsE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3602079..3602747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417920.1 cell division protein FtsE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417920.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AMZ6, A0A8S7E990
      Conserved Domains (1) summary
      PRK10908
      Location:1 → 222
      PRK10908; cell division ATP-binding protein FtsE
    Nucleotide Protein
    Heading Accession and Version

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