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    rutB ureidoacrylate amidohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945699, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rutB
    Official Full Name
    ureidoacrylate amidohydrolase
    Primary source
    ECOCYC:G6522
    Locus tag
    b1011
    See related
    ASAP:ABE-0003414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1002; ycdL
    Summary
    NtrC regulon. [More information is available at EcoGene: EG13858]. Escherichia coli K-12 contains a previously undescribed pathway for pyrimidine degradation. [More information is available at EcoCyc: G6522].
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    Genomic context

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    Sequence:
    NC_000913.3 (1072171..1072863, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative aminoacrylate hydrolase RutD Neighboring gene 3-aminoacrylate deaminase Neighboring gene pyrimidine monooxygenase RutA Neighboring gene DNA-binding transcriptional dual regulator RutR Neighboring gene fused DNA-binding transcriptional repressor/proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase PutA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli. Busch MR, et al. Biochemistry, 2023 Feb 7. PMID 36599150
    2. Comparative genomics reveals novel biochemical pathways. Piskur J, et al. Trends Genet, 2007 Aug. PMID 17555842
    3. A hidden metabolic pathway exposed. Osterman A. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595627, Free PMC Article
    4. The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. Kim KS, et al. J Bacteriol, 2010 Aug. PMID 20400551, Free PMC Article
    5. Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation. Zimmer DP, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121068, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli.
      Title: Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nitrogen utilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nitrogen utilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine nucleobase catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in uracil catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uracil catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within uracil catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ureidoacrylate amidohydrolase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1072171..1072863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415531.2 ureidoacrylate amidohydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415531.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0J2E7K8
      Conserved Domains (1) summary
      TIGR03614
      Location:3 → 228
      RutB; pyrimidine utilization protein B
    Nucleotide Protein
    Heading Accession and Version

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