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    Yes1 YES proto-oncogene 1, Src family tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 22612, updated on 9-Dec-2024

    Summary

    Official Symbol
    Yes1provided by MGI
    Official Full Name
    YES proto-oncogene 1, Src family tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:99147
    See related
    Ensembl:ENSMUSG00000014932 AllianceGenome:MGI:99147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Yes; p61-Yes
    Summary
    Enables protein tyrosine kinase activity. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; cellular response to retinoic acid; and positive regulation of macromolecule metabolic process. Located in actin filament and plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; gut; placenta; and vagal nerve trunk. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.0), CNS E11.5 (RPKM 3.5) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Yes1 in Genome Data Viewer
    Location:
    5 B1; 5 17.33 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32768502..32844410)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32611171..32687066)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12795 Neighboring gene protein phosphatase 1 catalytic subunit beta Neighboring gene predicted gene 15614 Neighboring gene methyltransferase-like protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12798 Neighboring gene STARR-seq mESC enhancer starr_12799 Neighboring gene STARR-positive B cell enhancer ABC_E8048 Neighboring gene STARR-seq mESC enhancer starr_12801 Neighboring gene predicted gene 10461 Neighboring gene STARR-seq mESC enhancer starr_12803 Neighboring gene predicted gene 2420 Neighboring gene predicted gene, 52771 Neighboring gene STARR-seq mESC enhancer starr_12804 Neighboring gene phosphatidylserine decarboxylase Neighboring gene STARR-positive B cell enhancer ABC_E4751

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase Yes
    Names
    Yamaguchi sarcoma viral (v-yes) oncogene homolog 1
    proto-oncogene c-Yes
    proto-oncogene tyrosine-protein kinase Yes
    viral oncogene yes homolog
    NP_001192061.1
    NP_001192062.1
    NP_033561.1
    XP_036020892.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205132.1NP_001192061.1  tyrosine-protein kinase Yes

      See identical proteins and their annotated locations for NP_001192061.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC091274, AC166934
      Consensus CDS
      CCDS39061.1
      UniProtKB/Swiss-Prot
      Q04736
      UniProtKB/TrEMBL
      Q3TJI7, Q8C762, Q8CBP1
      Related
      ENSMUSP00000144001.2, ENSMUST00000202543.4
      Conserved Domains (4) summary
      cd09933
      Location:152251
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:92149
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:262540
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
      pfam07714
      Location:275524
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001205133.1NP_001192062.1  tyrosine-protein kinase Yes

      See identical proteins and their annotated locations for NP_001192062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in both the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC091274, AC166934
      Consensus CDS
      CCDS39061.1
      UniProtKB/Swiss-Prot
      Q04736
      UniProtKB/TrEMBL
      Q3TJI7, Q8C762, Q8CBP1
      Related
      ENSMUSP00000132161.3, ENSMUST00000168707.6
      Conserved Domains (4) summary
      cd09933
      Location:152251
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:92149
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:262540
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
      pfam07714
      Location:275524
      Pkinase_Tyr; Protein tyrosine kinase
    3. NM_009535.3NP_033561.1  tyrosine-protein kinase Yes

      See identical proteins and their annotated locations for NP_033561.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC091274, AC166934, AK167420
      Consensus CDS
      CCDS39061.1
      UniProtKB/Swiss-Prot
      Q04736
      UniProtKB/TrEMBL
      Q3TJI7, Q8C762, Q8CBP1
      Related
      ENSMUSP00000072154.7, ENSMUST00000072311.13
      Conserved Domains (4) summary
      cd09933
      Location:152251
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:92149
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cd05069
      Location:262540
      PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
      pfam07714
      Location:275524
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      32768502..32844410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164999.1XP_036020892.1  tyrosine-protein kinase Yes isoform X1

      Conserved Domains (3) summary
      cd09933
      Location:152251
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd12007
      Location:92149
      SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
      cl21453
      Location:262351
      PKc_like; Protein Kinases, catalytic domain