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    Ppic peptidylprolyl isomerase C [ Mus musculus (house mouse) ]

    Gene ID: 19038, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppicprovided by MGI
    Official Full Name
    peptidylprolyl isomerase Cprovided by MGI
    Primary source
    MGI:MGI:97751
    See related
    Ensembl:ENSMUSG00000024538 AllianceGenome:MGI:97751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CyP-20c
    Summary
    Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human PPIC (peptidylprolyl isomerase C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 78.7), bladder adult (RPKM 64.9) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Ppic in Genome Data Viewer
    Location:
    18 D1; 18 29.03 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (53539413..53551079, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (53406341..53418007, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene sorting nexing 24 Neighboring gene predicted gene, 54042 Neighboring gene predicted gene, 57647 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44622 Neighboring gene STARR-seq mESC enhancer starr_44623 Neighboring gene predicted gene, 41726 Neighboring gene PR domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_44624

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase C
    Names
    PPIase C
    cyclophilin C
    rotamase C
    NP_032934.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008908.4NP_032934.1  peptidyl-prolyl cis-trans isomerase C precursor

      See identical proteins and their annotated locations for NP_032934.1

      Status: PROVISIONAL

      Source sequence(s)
      AC109291
      Consensus CDS
      CCDS29252.1
      UniProtKB/Swiss-Prot
      P30412
      UniProtKB/TrEMBL
      Q3UC73
      Related
      ENSMUSP00000025419.8, ENSMUST00000025419.9
      Conserved Domains (1) summary
      cd01926
      Location:38197
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      53539413..53551079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)