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    Prss3b serine protease 3B [ Mus musculus (house mouse) ]

    Gene ID: 67373, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss3bprovided by MGI
    Official Full Name
    serine protease 3Bprovided by MGI
    Primary source
    MGI:MGI:1914623
    See related
    Ensembl:ENSMUSG00000029882 AllianceGenome:MGI:1914623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T7; 2210010C04Rik
    Summary
    Enables serine-type endopeptidase activity. Acts upstream of or within zymogen activation. Predicted to be active in extracellular space. Is expressed in ductus deferens; gallbladder; pancreas; pancreas tip epithelium; and testis. Used to study pancreatitis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Prss3b in Genome Data Viewer
    Location:
    6 B1; 6 19.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41007202..41012443, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41030268..41035509, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810009J06 gene Neighboring gene T cell receptor beta chain Neighboring gene STARR-seq mESC enhancer starr_15692 Neighboring gene predicted gene 2663 Neighboring gene T cell receptor beta, variable 2 Neighboring gene T cell receptor beta, variable 3

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within zymogen activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    trypsinogen 7
    Names
    cationic trypsinogen (isoform T7)
    protease, serine 3B
    NP_075822.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_006980.1 

      Range
      139474..144715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_023333.4NP_075822.3  trypsinogen 7 precursor

      See identical proteins and their annotated locations for NP_075822.3

      Status: VALIDATED

      Source sequence(s)
      AK007943, AK008460, AK008695
      Consensus CDS
      CCDS20043.1
      UniProtKB/TrEMBL
      Q9CPN9, Q9D7Y7
      Related
      ENSMUSP00000031931.6, ENSMUST00000031931.6
      Conserved Domains (2) summary
      smart00020
      Location:24240
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:25243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      41007202..41012443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)