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    Timeless timeless circadian clock 1 [ Mus musculus (house mouse) ]

    Gene ID: 21853, updated on 9-Dec-2024

    Summary

    Official Symbol
    Timelessprovided by MGI
    Official Full Name
    timeless circadian clock 1provided by MGI
    Primary source
    MGI:MGI:1321393
    See related
    Ensembl:ENSMUSG00000039994 AllianceGenome:MGI:1321393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tim; Debt69
    Summary
    The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.3), limb E14.5 (RPKM 3.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Timeless in Genome Data Viewer
    Location:
    10 D3; 10 76.49 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128067932..128088810)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128232063..128252941)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutaminase 2 (liver, mitochondrial) Neighboring gene STARR-positive B cell enhancer ABC_E725 Neighboring gene STARR-positive B cell enhancer ABC_E10659 Neighboring gene SPRY domain containing 4 Neighboring gene predicted gene, 26847 Neighboring gene major intrinsic protein of lens fiber Neighboring gene STARR-seq mESC enhancer starr_28273 Neighboring gene apolipoprotein N Neighboring gene STARR-positive B cell enhancer ABC_E5199 Neighboring gene apolipoprotein F Neighboring gene signal transducer and activator of transcription 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to bleomycin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to bleomycin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to cisplatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cisplatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydroxyurea ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in morphogenesis of an epithelium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein timeless homolog
    Names
    mTim
    timeless homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136082.2NP_001129554.1  protein timeless homolog isoform 1

      See identical proteins and their annotated locations for NP_001129554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. This variant is distinct from but the same length as variant 3. The resulting isoform (1) lacks one aa near the C-terminus, compared to isoform 2, and is distinct from isoform 3.
      Source sequence(s)
      BC052884, BC082770
      Consensus CDS
      CCDS48725.1
      UniProtKB/Swiss-Prot
      Q9R1X4
      Related
      ENSMUSP00000100876.2, ENSMUST00000105242.8
      Conserved Domains (3) summary
      pfam05029
      Location:7221189
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:25284
      TIMELESS; Timeless protein
      cl10555
      Location:539611
      Chorismate_bind; chorismate binding enzyme
    2. NM_001164080.1NP_001157552.1  protein timeless homolog isoform 3

      See identical proteins and their annotated locations for NP_001157552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The resulting isoform (3) lacks one aa near the C-terminus, compared to isoform 2.
      Source sequence(s)
      AK153838, BC052884, BC082770
      Consensus CDS
      CCDS48724.1
      UniProtKB/TrEMBL
      Q3U574
      Related
      ENSMUSP00000100878.2, ENSMUST00000105244.8
      Conserved Domains (3) summary
      pfam05029
      Location:7221189
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:25284
      TIMELESS; Timeless protein
      cl10555
      Location:539611
      Chorismate_bind; chorismate binding enzyme
    3. NM_001164081.1NP_001157553.1  protein timeless homolog isoform 2

      See identical proteins and their annotated locations for NP_001157553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (2). Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      BC052884, BC082770, CJ088470
      Consensus CDS
      CCDS24266.1
      UniProtKB/Swiss-Prot
      Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R1X4, Q9R268, Q9Z0E7
      Related
      ENSMUSP00000058021.5, ENSMUST00000055539.11
      Conserved Domains (2) summary
      pfam05029
      Location:7221190
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:25284
      TIMELESS; Timeless protein
    4. NM_011589.2NP_035719.1  protein timeless homolog isoform 2

      See identical proteins and their annotated locations for NP_035719.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 4. Both variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AF098161, BC082770
      Consensus CDS
      CCDS24266.1
      UniProtKB/Swiss-Prot
      Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R1X4, Q9R268, Q9Z0E7
      Related
      ENSMUSP00000100879.3, ENSMUST00000105245.3
      Conserved Domains (2) summary
      pfam05029
      Location:7221190
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:25284
      TIMELESS; Timeless protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128067932..128088810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245050.1XP_030100910.1  protein timeless homolog isoform X6

      Conserved Domains (1) summary
      pfam05029
      Location:365833
      TIMELESS_C; Timeless protein C terminal region
    2. XM_030245049.2XP_030100909.1  protein timeless homolog isoform X4

      Conserved Domains (2) summary
      pfam05029
      Location:7831249
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:86345
      TIMELESS; Timeless protein
    3. XM_006513582.3XP_006513645.1  protein timeless homolog isoform X3

      Conserved Domains (2) summary
      pfam05029
      Location:7831250
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:86345
      TIMELESS; Timeless protein
    4. XM_006513581.5XP_006513644.1  protein timeless homolog isoform X2

      Conserved Domains (2) summary
      pfam05029
      Location:7831250
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:86345
      TIMELESS; Timeless protein
    5. XM_006513580.3XP_006513643.1  protein timeless homolog isoform X1

      Conserved Domains (2) summary
      pfam05029
      Location:7831251
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:86345
      TIMELESS; Timeless protein
    6. XM_006513583.3XP_006513646.1  protein timeless homolog isoform X5

      See identical proteins and their annotated locations for XP_006513646.1

      UniProtKB/Swiss-Prot
      Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R1X4, Q9R268, Q9Z0E7
      Conserved Domains (2) summary
      pfam05029
      Location:7221190
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:25284
      TIMELESS; Timeless protein