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    Ssbp1 single-stranded DNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 381760, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ssbp1provided by MGI
    Official Full Name
    single-stranded DNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1920040
    See related
    Ensembl:ENSMUSG00000029911 AllianceGenome:MGI:1920040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MtSSB; mtDBP; 2810480P10Rik; G630031O20Rik
    Summary
    Predicted to enable chromatin binding activity; protein homodimerization activity; and single-stranded DNA binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in brain ventricular layer; foregut; renal cortex; and submandibular gland primordium. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human SSBP1 (single stranded DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 17.1), CNS E14 (RPKM 12.3) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ssbp1 in Genome Data Viewer
    Location:
    6 B1; 6 18.82 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40448302..40458757)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40471414..40481823)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15678 Neighboring gene acylglycerol kinase Neighboring gene STARR-seq mESC enhancer starr_15681 Neighboring gene STARR-seq mESC enhancer starr_15684 Neighboring gene DENN domain containing 11 Neighboring gene WEE1 homolog 2 (S. pombe) Neighboring gene STARR-seq mESC enhancer starr_15685 Neighboring gene taste receptor, type 2, member 137 Neighboring gene taste receptor, type 2, member 108

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA unwinding involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    single-stranded DNA-binding protein, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286663.1NP_001273592.1  single-stranded DNA-binding protein, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001273592.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and includes an alternate 3' terminal exon, compared to variant 2. Variants 1, 3, and 5 encode the same isoform (1) which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      BC028648, BC060290
      Consensus CDS
      CCDS39466.1
      UniProtKB/TrEMBL
      Q8R2K3
      Related
      ENSMUSP00000113563.2, ENSMUST00000121360.8
      Conserved Domains (1) summary
      TIGR00621
      Location:27141
      ssb; single stranded DNA-binding protein (ssb)
    2. NM_001364578.1NP_001351507.1  single-stranded DNA-binding protein, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC155653, AI509168, AK013425, BC028648
      Consensus CDS
      CCDS39466.1
      UniProtKB/TrEMBL
      Q8R2K3
      Related
      ENSMUSP00000114082.2, ENSMUST00000117411.8
      Conserved Domains (1) summary
      TIGR00621
      Location:27141
      ssb; single stranded DNA-binding protein (ssb)
    3. NM_028358.2NP_082634.1  single-stranded DNA-binding protein, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_082634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AK013425
      Consensus CDS
      CCDS20030.1
      UniProtKB/Swiss-Prot
      Q9CYR0
      Related
      ENSMUSP00000031971.7, ENSMUST00000031971.13
      Conserved Domains (1) summary
      cl09930
      Location:27134
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    4. NM_212468.3NP_997633.1  single-stranded DNA-binding protein, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_997633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) includes an alternate 3' terminal exon, compared to variant 1. Variants 1, 3, and 5 encode the same isoform (1) which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AK013425, BC028648
      Consensus CDS
      CCDS39466.1
      UniProtKB/TrEMBL
      Q8R2K3
      Related
      ENSMUSP00000110427.3, ENSMUST00000114779.9
      Conserved Domains (1) summary
      TIGR00621
      Location:27141
      ssb; single stranded DNA-binding protein (ssb)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      40448302..40458757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321664.3XP_017177153.1  single-stranded DNA-binding protein, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9CYR0
      Conserved Domains (1) summary
      cl09930
      Location:27134
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    2. XM_006506329.3XP_006506392.1  single-stranded DNA-binding protein, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006506392.1

      UniProtKB/Swiss-Prot
      Q9CYR0
      Conserved Domains (1) summary
      cl09930
      Location:27134
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.