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    Ctsa cathepsin A [ Mus musculus (house mouse) ]

    Gene ID: 19025, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctsaprovided by MGI
    Official Full Name
    cathepsin Aprovided by MGI
    Primary source
    MGI:MGI:97748
    See related
    Ensembl:ENSMUSG00000017760 AllianceGenome:MGI:97748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PPCA; Ppgb
    Summary
    This gene encodes a glycoprotein with deamidase, esterase and carboxypeptidase activities. The encoded protein associates with and provides a protective function to the lysosomal enzymes beta-galactosidase and neuraminidase. Deficiency of the related gene in humans results in galactosialidosis. The proprotein is processed into two shorter chains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in lung adult (RPKM 116.6), kidney adult (RPKM 99.9) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ctsa in Genome Data Viewer
    Location:
    2 H3; 2 85.27 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164674792..164682952)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164832872..164841032)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06336 Neighboring gene zinc finger SWIM-type containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6018 Neighboring gene spermatogenesis associated 25 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164659262-164659371 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene phospholipid transfer protein Neighboring gene STARR-seq mESC enhancer starr_06339 Neighboring gene RIKEN cDNA 4930445K14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6019 Neighboring gene STARR-positive B cell enhancer ABC_E2059 Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene predicted gene, 46775

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type carboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of chaperone-mediated autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chaperone-mediated autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    lysosomal protective protein
    Names
    carboxypeptidase C
    carboxypeptidase L
    protective protein cathepsin A
    protective protein for beta-galactosidase
    NP_001033581.1
    NP_032932.2
    XP_030104427.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038492.2NP_001033581.1  lysosomal protective protein isoform b preproprotein

      See identical proteins and their annotated locations for NP_001033581.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and initiates translation at an alternate downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK019861, AK032197, AL591495, BY319945
      Consensus CDS
      CCDS17062.1
      UniProtKB/Swiss-Prot
      P16675, Q8VEF6
      UniProtKB/TrEMBL
      Q544R6, Q9D2D1
      Related
      ENSMUSP00000099382.4, ENSMUST00000103093.10
      Conserved Domains (1) summary
      pfam00450
      Location:34470
      Peptidase_S10; Serine carboxypeptidase
    2. NM_008906.4NP_032932.2  lysosomal protective protein isoform a preproprotein

      See identical proteins and their annotated locations for NP_032932.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK019861, AK032197, AK159150, AL591495
      Consensus CDS
      CCDS17061.1
      UniProtKB/TrEMBL
      G3X8T3, Q9D2D1
      Conserved Domains (1) summary
      pfam00450
      Location:52488
      Peptidase_S10; Serine carboxypeptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164674792..164682952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248567.2XP_030104427.1  lysosomal protective protein isoform X1

      UniProtKB/TrEMBL
      G3X8T3, Q9D2D1
      Related
      ENSMUSP00000099381.3, ENSMUST00000103092.9
      Conserved Domains (1) summary
      pfam00450
      Location:52488
      Peptidase_S10; Serine carboxypeptidase