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    Ctbp1 C-terminal binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13016, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctbp1provided by MGI
    Official Full Name
    C-terminal binding protein 1provided by MGI
    Primary source
    MGI:MGI:1201685
    See related
    Ensembl:ENSMUSG00000037373 AllianceGenome:MGI:1201685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BARS; D4S115h; D5H4S115; D5H4S115E; CtBP3/BARS
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and chromatin binding activity. Involved in negative regulation of DNA-templated transcription; synaptic vesicle cycle; and white fat cell differentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is expressed in several structures, including central nervous system; genitourinary system; limb; lung; and neural retina. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 109.8), CNS E14 (RPKM 100.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ctbp1 in Genome Data Viewer
    Location:
    5 B1; 5 17.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33405067..33432348, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33247723..33275004, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene spondin 2, extracellular matrix protein Neighboring gene predicted gene, 54327 Neighboring gene STARR-positive B cell enhancer ABC_E8049 Neighboring gene predicted gene, 51410 Neighboring gene predicted gene 20465

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lncRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coregulator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C-terminal-binding protein 1
    NP_001185788.1
    NP_001185789.1
    NP_001185790.1
    NP_001297464.1
    NP_001408504.1
    NP_038530.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198859.1NP_001185788.1  C-terminal-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001185788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. It encodes a shorter isoform (1) compared to isoform 3.
      Source sequence(s)
      AJ010483, BE991938, CJ163412
      UniProtKB/Swiss-Prot
      O88712
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    2. NM_001198860.1NP_001185789.1  C-terminal-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001185789.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes a shorter isoform (2) with a distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AJ010483, BE991938, CJ163412
      Consensus CDS
      CCDS80256.1
      UniProtKB/TrEMBL
      A0A0J9YU62
      Related
      ENSMUSP00000144024.2, ENSMUST00000202868.4
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    3. NM_001198861.1NP_001185790.1  C-terminal-binding protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001185790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' region and initiates translation at an alternate start codon, compared to variant 3. It encodes a shorter isoform (4) with a distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AK133816, BE991938, CJ163412
      UniProtKB/Swiss-Prot
      O88712
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    4. NM_001310535.1NP_001297464.1  C-terminal-binding protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 3. It encodes a shorter isoform (5) with a shorter N-terminus compared to isoform 3.
      Source sequence(s)
      AC115070
      Consensus CDS
      CCDS80255.1
      UniProtKB/Swiss-Prot
      O88712
      Related
      ENSMUSP00000144554.2, ENSMUST00000201575.4
      Conserved Domains (1) summary
      cd05299
      Location:7272
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    5. NM_001421575.1NP_001408504.1  C-terminal-binding protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC115070
    6. NM_013502.3NP_038530.1  C-terminal-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_038530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AK133816, BE991938, CJ163412
      Consensus CDS
      CCDS19201.1
      UniProtKB/Swiss-Prot
      O88712, Q3TAT1, Q3TDL5, Q3TUM5, Q91WI6, Q91YX3, Q9QYG2
      Related
      ENSMUSP00000078682.7, ENSMUST00000079746.10
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      33405067..33432348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)