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    Nmi N-myc (and STAT) interactor [ Mus musculus (house mouse) ]

    Gene ID: 64685, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nmiprovided by MGI
    Official Full Name
    N-myc (and STAT) interactorprovided by MGI
    Primary source
    MGI:MGI:1928368
    See related
    Ensembl:ENSMUSG00000026946 AllianceGenome:MGI:1928368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity. Involved in positive regulation of inflammatory response; response to virus; and toll-like receptor 4 signaling pathway. Acts upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Located in extracellular space. Is expressed in genitourinary system; limb; and retina. Orthologous to human NMI (N-myc and STAT interactor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.8), large intestine adult (RPKM 5.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nmi in Genome Data Viewer
    Location:
    2 C1.1; 2 29.98 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (51838517..51863241, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (51948498..51973489, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13495 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene STARR-seq mESC enhancer starr_04475 Neighboring gene tumor necrosis factor alpha induced protein 6 Neighboring gene STARR-seq mESC enhancer starr_04477 Neighboring gene replication timing regulatory factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of type I interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    N-myc-interactor
    Names
    N-mcy (and STAT) interactor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141948.2NP_001135420.1  N-myc-interactor isoform a

      See identical proteins and their annotated locations for NP_001135420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL929026
      Consensus CDS
      CCDS16031.1
      UniProtKB/Swiss-Prot
      O35309, Q99M49
      UniProtKB/TrEMBL
      Q3UJ82, Q4FJP2
      Related
      ENSMUSP00000108325.3, ENSMUST00000112705.9
      Conserved Domains (2) summary
      pfam07334
      Location:30105
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:204292
      NID; Nmi/IFP 35 domain (NID)
    2. NM_001141949.2NP_001135421.1  N-myc-interactor isoform a

      See identical proteins and their annotated locations for NP_001135421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL929026
      Consensus CDS
      CCDS16031.1
      UniProtKB/Swiss-Prot
      O35309, Q99M49
      UniProtKB/TrEMBL
      Q3UJ82, Q4FJP2
      Related
      ENSMUSP00000120647.2, ENSMUST00000145481.8
      Conserved Domains (2) summary
      pfam07334
      Location:30105
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:204292
      NID; Nmi/IFP 35 domain (NID)
    3. NM_001421887.1NP_001408816.1  N-myc-interactor isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL929026
      UniProtKB/Swiss-Prot
      O35309, Q99M49
      UniProtKB/TrEMBL
      Q3UJ82, Q4FJP2
    4. NM_001421888.1NP_001408817.1  N-myc-interactor isoform b

      Status: VALIDATED

      Source sequence(s)
      AL929026
      UniProtKB/TrEMBL
      Q4FJP2
    5. NM_001421889.1NP_001408818.1  N-myc-interactor isoform c

      Status: VALIDATED

      Source sequence(s)
      AL929026
    6. NM_001421890.1NP_001408819.1  N-myc-interactor isoform c

      Status: VALIDATED

      Source sequence(s)
      AL929026
    7. NM_001421891.1NP_001408820.1  N-myc-interactor isoform c

      Status: VALIDATED

      Source sequence(s)
      AL929026
    8. NM_019401.3NP_062274.1  N-myc-interactor isoform a

      See identical proteins and their annotated locations for NP_062274.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL929026
      Consensus CDS
      CCDS16031.1
      UniProtKB/Swiss-Prot
      O35309, Q99M49
      UniProtKB/TrEMBL
      Q3UJ82, Q4FJP2
      Related
      ENSMUSP00000028314.3, ENSMUST00000028314.9
      Conserved Domains (2) summary
      pfam07334
      Location:30105
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:204292
      NID; Nmi/IFP 35 domain (NID)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      51838517..51863241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)