U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ubiF 3-demethoxyubiquinol 3-hydroxylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945261, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ubiF
    Official Full Name
    3-demethoxyubiquinol 3-hydroxylase
    Primary source
    ECOCYC:G6365
    Locus tag
    b0662
    See related
    ASAP:ABE-0002265
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0654; yleB
    Summary
    visC, ubiH, ubiF and mhpA are paralogs. [More information is available at EcoGene: EG13658]. 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase catalyzes the third monooxygenase reaction in the ubiquinone biosynthesis pathway. [More information is available at EcoCyc: G6365].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (695101..696276)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene endoribonuclease YbeY Neighboring gene PhoH-like protein Neighboring gene isopentenyl-adenosine A37 tRNA methylthiolase Neighboring gene tRNA-Gln Neighboring gene tRNA-Gln

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An Escherichia coli mutant resistant to phleomycin, bleomycin, and heat inactivation is defective in ubiquinone synthesis. Collis CM, et al. J Bacteriol, 1989 Sep. PMID 2475481, Free PMC Article
    2. Characterization of a respiratory mutant of Escherichia coli with reduced uptake of aminoglycoside antibiotics. Muir ME, et al. Biochim Biophys Acta, 1981 Dec 14. PMID 7032590
    3. Energy production genes sucB and ubiF are involved in persister survival and tolerance to multiple antibiotics and stresses in Escherichia coli. Ma C, et al. FEMS Microbiol Lett, 2010 Feb. PMID 20041955
    4. Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone. Young IG, et al. J Bacteriol, 1971 Mar. PMID 4323297, Free PMC Article
    5. Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1, a product of the longevity gene of the nematode worm. Adachi A, et al. FEBS Lett, 2003 May 22. PMID 12753928

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sucB and ubiF mutants deficient in energy production were identified from the mutant screens to have defective persister survival as demonstrated by higher susceptibility to various antibiotics and different stresses.
      Title: Energy production genes sucB and ubiF are involved in persister survival and tolerance to multiple antibiotics and stresses in Escherichia coli.
    2. 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase
      Title: Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-demethoxyubiquinol 3-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-demethoxyubiquinol 3-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-demethoxyubiquinol 3-hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquinone biosynthesis complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    3-demethoxyubiquinol 3-hydroxylase
    NP_415195.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      695101..696276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415195.1 3-demethoxyubiquinol 3-hydroxylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415195.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EKU4, A0A8T3UNI4
      Conserved Domains (1) summary
      PRK08020
      Location:1 → 391
      ubiF; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.