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    Rnase2b ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin) [ Mus musculus (house mouse) ]

    Gene ID: 54159, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnase2bprovided by MGI
    Official Full Name
    ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)provided by MGI
    Primary source
    MGI:MGI:1858598
    See related
    Ensembl:ENSMUSG00000059606 AllianceGenome:MGI:1858598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mR5; Ear5; Raf4
    Summary
    Predicted to enable RNA nuclease activity and lipopolysaccharide binding activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to several human genes including RNASE2 (ribonuclease A family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Rnase2b in Genome Data Viewer
    Location:
    14 C1; 14 26.4 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51399717..51400475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51162260..51163018)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9895 Neighboring gene ribonuclease, RNase A family, 6 Neighboring gene ribonuclease, RNase A family, 1 (pancreatic) Neighboring gene eosinophil-associated, ribonuclease A family, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_36667 Neighboring gene STARR-seq mESC enhancer starr_36668 Neighboring gene angiogenin, ribonuclease A family, member 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Clone Names

    • MGC143624

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonuclease A activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response in mucosa IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribonuclease 2B
    Names
    MR-5
    eosinophil cationic-type ribonuclease 5
    eosinophil-associated ribonuclease 5
    eosinophil-associated, ribonuclease A family, member 5
    murine ribonuclease 5
    ribonuclease A f4
    NP_062271.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019398.2NP_062271.2  ribonuclease 2B precursor

      See identical proteins and their annotated locations for NP_062271.2

      Status: VALIDATED

      Source sequence(s)
      AC163664
      Consensus CDS
      CCDS27039.1
      UniProtKB/Swiss-Prot
      O35292, Q8K416
      UniProtKB/TrEMBL
      Q0VDV3, W0UVC5
      Related
      ENSMUSP00000075074.4, ENSMUST00000075648.4
      Conserved Domains (1) summary
      pfam00074
      Location:29152
      RnaseA; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51399717..51400475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)