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    Prss59 serine protease 59 [ Mus musculus (house mouse) ]

    Gene ID: 73481, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss59provided by MGI
    Official Full Name
    serine protease 59provided by MGI
    Primary source
    MGI:MGI:1920731
    See related
    Ensembl:ENSMUSG00000029883 AllianceGenome:MGI:1920731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tryx5; 1700074P13Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Located in Golgi apparatus. Orthologous to human PRSS59P (serine protease 59, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 86.3) See more
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    Genomic context

    See Prss59 in Genome Data Viewer
    Location:
    6 B1; 6 18.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40897371..40917975, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40920437..40941041, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15690 Neighboring gene serine protease 58 Neighboring gene T cell receptor beta, variable 1 Neighboring gene RIKEN cDNA 1810009J06 gene Neighboring gene T cell receptor beta chain Neighboring gene trypsinogen pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    trypsin X5
    Names
    protease, serine 59

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_006980.1 

      Range
      29643..49763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361930.1NP_001348859.1  trypsin X5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC161768, BC061035
      Consensus CDS
      CCDS20041.1
      UniProtKB/TrEMBL
      Q9D9G7
      Related
      ENSMUSP00000112987.2, ENSMUST00000122181.8
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_028550.4NP_082826.1  trypsin X5 precursor

      See identical proteins and their annotated locations for NP_082826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC161768, AK030264, BC061035
      Consensus CDS
      CCDS20041.1
      UniProtKB/TrEMBL
      Q9D9G7
      Related
      ENSMUSP00000031935.4, ENSMUST00000031935.10
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      40897371..40917975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506693.4XP_006506756.1  trypsin X5 isoform X2

      See identical proteins and their annotated locations for XP_006506756.1

      Conserved Domains (1) summary
      cl21584
      Location:36243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_030255627.1XP_030111487.1  trypsin X5 isoform X1

      UniProtKB/TrEMBL
      Q9D9G7
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_030255628.1XP_030111488.1  trypsin X5 isoform X1

      UniProtKB/TrEMBL
      Q9D9G7
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_017321780.2XP_017177269.1  trypsin X5 isoform X1

      UniProtKB/TrEMBL
      Q9D9G7
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. XM_017321779.2XP_017177268.1  trypsin X5 isoform X1

      UniProtKB/TrEMBL
      Q9D9G7
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    6. XM_017321778.2XP_017177267.1  trypsin X5 isoform X1

      UniProtKB/TrEMBL
      Q9D9G7
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    7. XM_030255629.1XP_030111489.1  trypsin X5 isoform X1

      UniProtKB/TrEMBL
      Q9D9G7
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    8. XM_030255633.1XP_030111493.1  trypsin X5 isoform X2

      Conserved Domains (1) summary
      cl21584
      Location:36243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    9. XM_030255630.1XP_030111490.1  trypsin X5 isoform X2

      Conserved Domains (1) summary
      cl21584
      Location:36243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    10. XM_030255632.1XP_030111492.1  trypsin X5 isoform X2

      Conserved Domains (1) summary
      cl21584
      Location:36243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    11. XM_030255631.1XP_030111491.1  trypsin X5 isoform X2

      Conserved Domains (1) summary
      cl21584
      Location:36243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    12. XM_011241489.4XP_011239791.1  trypsin X5 isoform X2

      See identical proteins and their annotated locations for XP_011239791.1

      Conserved Domains (1) summary
      cl21584
      Location:36243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    13. XM_011241488.3XP_011239790.1  trypsin X5 isoform X1

      See identical proteins and their annotated locations for XP_011239790.1

      UniProtKB/TrEMBL
      Q9D9G7
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...