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    Asgr2 asialoglycoprotein receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 11890, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asgr2provided by MGI
    Official Full Name
    asialoglycoprotein receptor 2provided by MGI
    Primary source
    MGI:MGI:88082
    See related
    Ensembl:ENSMUSG00000040963 AllianceGenome:MGI:88082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asgr; HL-2; ASGPR2; Asgr-2
    Summary
    This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in liver adult (RPKM 69.1), liver E18 (RPKM 23.8) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Asgr2 in Genome Data Viewer
    Location:
    11 B3; 11 42.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69983470..69997013)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70092644..70106187)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene asialoglycoprotein receptor 1 Neighboring gene predicted gene, 32946 Neighboring gene predicted gene 12311 Neighboring gene macrophage galactose N-acetyl-galactosamine specific lectin 2 Neighboring gene C-type lectin domain family 10, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fucose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glycoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum quality control compartment ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    asialoglycoprotein receptor 2
    Names
    hepatic lectin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313925.1NP_001300854.1  asialoglycoprotein receptor 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AI227223, AL596185, X53042
      Consensus CDS
      CCDS24934.1
      UniProtKB/Swiss-Prot
      P24721
      Conserved Domains (2) summary
      cd03590
      Location:170295
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:29162
      Lectin_N; Hepatic lectin, N-terminal domain
    2. NM_001313926.1NP_001300855.1  asialoglycoprotein receptor 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL596185, X53042
      Consensus CDS
      CCDS24934.1
      UniProtKB/Swiss-Prot
      P24721
      Conserved Domains (2) summary
      cd03590
      Location:170295
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:29162
      Lectin_N; Hepatic lectin, N-terminal domain
    3. NM_001313927.1NP_001300856.1  asialoglycoprotein receptor 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (b) with a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AL596185, X53042
      UniProtKB/TrEMBL
      J3QMY0
      Related
      ENSMUSP00000136505.2, ENSMUST00000143772.8
      Conserved Domains (2) summary
      cd03590
      Location:67192
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:159
      Lectin_N; Hepatic lectin, N-terminal domain
    4. NM_007493.3NP_031519.1  asialoglycoprotein receptor 2 isoform a

      See identical proteins and their annotated locations for NP_031519.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL596185
      Consensus CDS
      CCDS24934.1
      UniProtKB/Swiss-Prot
      P24721
      Related
      ENSMUSP00000099632.2, ENSMUST00000102572.8
      Conserved Domains (2) summary
      cd03590
      Location:170295
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:29162
      Lectin_N; Hepatic lectin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69983470..69997013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)