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    Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) [ Mus musculus (house mouse) ]

    Gene ID: 16913, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psmb8provided by MGI
    Official Full Name
    proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)provided by MGI
    Primary source
    MGI:MGI:1346527
    See related
    Ensembl:ENSMUSG00000024338 AllianceGenome:MGI:1346527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmp7; Lmp-7
    Summary
    Predicted to enable endopeptidase activity. Involved in fat cell differentiation. Acts upstream of or within antigen processing and presentation. Part of proteasome core complex and spermatoproteasome complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to human PSMB8 (proteasome 20S subunit beta 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 141.3), large intestine adult (RPKM 117.3) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Psmb8 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34417169..34420428)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34198195..34201454)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42425 Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) Neighboring gene transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34333284-34333657 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34347631-34347818 Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene STARR-positive B cell enhancer ABC_E4208 Neighboring gene STARR-positive B cell enhancer ABC_E4209 Neighboring gene STARR-positive B cell enhancer ABC_E4210 Neighboring gene histocompatibility 2, O region beta locus

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spermatoproteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome subunit beta type-8
    Names
    MC13 (LMP7)
    large multifunctional protease 7
    low molecular mass protein 7
    macropain subunit C13
    multicatalytic endopeptidase complex subunit C13
    proteasome component C13
    proteasome subunit MC13
    proteasome subunit beta-5i
    proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
    proteosome beta 8 subunit
    NP_034854.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010724.2NP_034854.2  proteasome subunit beta type-8

      See identical proteins and their annotated locations for NP_034854.2

      Status: VALIDATED

      Source sequence(s)
      AK031801, AK150674, CJ235673
      Consensus CDS
      CCDS50073.1
      UniProtKB/Swiss-Prot
      P28063, Q3UK42, Q64300, Q792S8, Q7TMX9, Q91VH7
      UniProtKB/TrEMBL
      A0A068BIT8
      Related
      ENSMUSP00000025196.9, ENSMUST00000025196.9
      Conserved Domains (2) summary
      PTZ00488
      Location:40271
      PTZ00488; Proteasome subunit beta type-5; Provisional
      cd03761
      Location:73260
      proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34417169..34420428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)