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    Msln mesothelin [ Mus musculus (house mouse) ]

    Gene ID: 56047, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mslnprovided by MGI
    Official Full Name
    mesothelinprovided by MGI
    Primary source
    MGI:MGI:1888992
    See related
    Ensembl:ENSMUSG00000063011 AllianceGenome:MGI:1888992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPF
    Summary
    Predicted to be involved in cell-matrix adhesion. Located in extracellular space. Is expressed in several structures, including body cavity or lining; genitourinary system; gut; heart; and respiratory system. Human ortholog(s) of this gene implicated in ovarian cancer; pancreas disease; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human MSLN (mesothelin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 25.5), ovary adult (RPKM 11.4) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Msln in Genome Data Viewer
    Location:
    17 A3.3; 17 12.85 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25967587..25973352, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25748613..25754378, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CTF18, chromosome transmission fidelity factor 18 Neighboring gene STARR-positive B cell enhancer ABC_E3190 Neighboring gene RNA pseudouridylate synthase domain containing 1 Neighboring gene mesothelin-like Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mesothelin
    Names
    megakaryocyte potentiating factor
    pre-pro-megakaryocyte-potentiating factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356286.1NP_001343215.1  mesothelin isoform 1 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK144391, D86370
      Consensus CDS
      CCDS28526.1
      UniProtKB/Swiss-Prot
      Q61468
      Related
      ENSMUSP00000158474.2, ENSMUST00000237359.2
      Conserved Domains (1) summary
      pfam06060
      Location:1624
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
    2. NM_001374653.1NP_001361582.1  mesothelin isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC134908
      UniProtKB/TrEMBL
      A0A494B9A6
      Related
      ENSMUSP00000157558.2, ENSMUST00000236137.2
      Conserved Domains (1) summary
      pfam06060
      Location:1628
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
    3. NM_018857.2NP_061345.1  mesothelin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_061345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) retains an intron in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK144391, AK146799, D86370
      Consensus CDS
      CCDS28526.1
      UniProtKB/Swiss-Prot
      Q61468
      Related
      ENSMUSP00000158357.2, ENSMUST00000238120.2
      Conserved Domains (1) summary
      pfam06060
      Location:1624
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25967587..25973352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)