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    Znfx1 zinc finger, NFX1-type containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 98999, updated on 9-Dec-2024

    Summary

    Official Symbol
    Znfx1provided by MGI
    Official Full Name
    zinc finger, NFX1-type containing 1provided by MGI
    Primary source
    MGI:MGI:2138982
    See related
    Ensembl:ENSMUSG00000039501 AllianceGenome:MGI:2138982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Astx3
    Summary
    Enables RNA binding activity. Involved in activation of innate immune response; defense response to virus; and negative regulation of viral genome replication. Is active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human ZNFX1 (zinc finger NFX1-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 12.8), genital fat pad adult (RPKM 12.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Znfx1 in Genome Data Viewer
    Location:
    2 H3; 2 87.22 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166877713..166904926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167035790..167063015, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2656 Neighboring gene DEAD box helicase 27 Neighboring gene STARR-positive B cell enhancer ABC_E6022 Neighboring gene predicted gene, 25878 Neighboring gene zinc finger, NFX1-type containing 1, antisense RNA 1 Neighboring gene predicted gene, 23201

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulatory ncRNA-mediated heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear RNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NFX1-type zinc finger-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033196.3NP_001028368.2  NFX1-type zinc finger-containing protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL591711
      Consensus CDS
      CCDS38337.1
      UniProtKB/Swiss-Prot
      A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151
      Related
      ENSMUSP00000049404.8, ENSMUST00000048988.14
      Conserved Domains (6) summary
      cd06008
      Location:14531497
      NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
      PRK03918
      Location:15971808
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd18808
      Location:10681244
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd17936
      Location:9711066
      EEXXEc_NFX1; EEXXE-box helicase domain of NFX1
      pfam01500
      Location:14251563
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam13086
      Location:8971031
      AAA_11; AAA domain
    2. NM_001291162.2NP_001278091.1  NFX1-type zinc finger-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AL591711
      Consensus CDS
      CCDS71198.1
      UniProtKB/TrEMBL
      A2A5R6
      Related
      ENSMUSP00000072867.6, ENSMUST00000067584.7
      Conserved Domains (4) summary
      cd06008
      Location:589633
      NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
      COG1112
      Location:63383
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam15042
      Location:626690
      LELP1; Late cornified envelope-like proline-rich protein 1
      cl22977
      Location:180363
      UvrD_C_2; UvrD-like helicase C-terminal domain
    3. NM_001424669.1NP_001411598.1  NFX1-type zinc finger-containing protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL591711
      UniProtKB/Swiss-Prot
      A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151
    4. NM_001424676.1NP_001411605.1  NFX1-type zinc finger-containing protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL591711
      UniProtKB/Swiss-Prot
      A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      166877713..166904926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)