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    Marco macrophage receptor with collagenous structure [ Mus musculus (house mouse) ]

    Gene ID: 17167, updated on 9-Dec-2024

    Summary

    Official Symbol
    Marcoprovided by MGI
    Official Full Name
    macrophage receptor with collagenous structureprovided by MGI
    Primary source
    MGI:MGI:1309998
    See related
    Ensembl:ENSMUSG00000026390 AllianceGenome:MGI:1309998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly112; Scara2
    Summary
    Predicted to enable amyloid-beta binding activity and cargo receptor activity. Acts upstream of or within apoptotic cell clearance. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in extracellular matrix and extracellular space. Is expressed in spleen. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 27.1), liver E14 (RPKM 17.6) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Marco in Genome Data Viewer
    Location:
    1 E2.3; 1 52.71 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (120402267..120432753, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120474538..120505024, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent-like 2 Neighboring gene STARR-seq mESC enhancer starr_02057 Neighboring gene predicted gene, 46154 Neighboring gene STARR-seq mESC enhancer starr_02059 Neighboring gene STARR-seq mESC enhancer starr_02060 Neighboring gene STARR-seq mESC enhancer starr_02061 Neighboring gene STARR-seq mESC enhancer starr_02062 Neighboring gene predicted gene, 41939 Neighboring gene STARR-seq mESC enhancer starr_02064 Neighboring gene engrailed 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cargo receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix structural constituent conferring tensile strength IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid-beta clearance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010766.3NP_034896.1  macrophage receptor MARCO

      See identical proteins and their annotated locations for NP_034896.1

      Status: VALIDATED

      Source sequence(s)
      AA185896, BC132338
      Consensus CDS
      CCDS15234.1
      UniProtKB/Swiss-Prot
      Q60754
      UniProtKB/TrEMBL
      A2RT24, Q3TF99
      Related
      ENSMUSP00000027639.2, ENSMUST00000027639.8
      Conserved Domains (3) summary
      pfam01391
      Location:150207
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:423518
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:428518
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      120402267..120432753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)