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    Ell elongation factor RNA polymerase II [ Mus musculus (house mouse) ]

    Gene ID: 13716, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ellprovided by MGI
    Official Full Name
    elongation factor RNA polymerase IIprovided by MGI
    Primary source
    MGI:MGI:109377
    See related
    Ensembl:ENSMUSG00000070002 AllianceGenome:MGI:109377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Men; Ell1
    Summary
    Predicted to enable cis-regulatory region sequence-specific DNA binding activity and phosphatase binding activity. Involved in snRNA transcription by RNA polymerase II. Acts upstream of or within in utero embryonic development. Predicted to be located in cytosol; euchromatin; and nuclear body. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including abdomen; central nervous system; genitourinary system; intestine; and liver. Orthologous to human ELL (elongation factor for RNA polymerase II). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 19.6), colon adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ell in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70992345..71045508)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70539675..70592858)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21774 Neighboring gene KxDL motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9315 Neighboring gene FK506 binding protein 8 Neighboring gene predicted gene, 51534 Neighboring gene STARR-positive B cell enhancer ABC_E2264 Neighboring gene STARR-positive B cell enhancer ABC_E1369 Neighboring gene myo-inositol 1-phosphate synthase A1 Neighboring gene single stranded DNA binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription elongation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in snRNA transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in snRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in snRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in snRNA transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in snRNA transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in histone locus body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in histone locus body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription elongation factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    RNA polymerase II elongation factor ELL
    Names
    RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN)
    eleven-nineteen lysine-rich leukemia protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007924.3NP_031950.2  RNA polymerase II elongation factor ELL

      See identical proteins and their annotated locations for NP_031950.2

      Status: VALIDATED

      Source sequence(s)
      AC157774
      Consensus CDS
      CCDS22372.1
      UniProtKB/Swiss-Prot
      O08856, Q3TXY9
      Related
      ENSMUSP00000091163.7, ENSMUST00000093454.8
      Conserved Domains (2) summary
      pfam07303
      Location:497594
      Occludin_ELL; Occludin homology domain
      pfam10390
      Location:6287
      ELL; RNA polymerase II elongation factor ELL

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70992345..71045508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)