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    Sirpa signal-regulatory protein alpha [ Mus musculus (house mouse) ]

    Gene ID: 19261, updated on 3-Dec-2024

    Summary

    Official Symbol
    Sirpaprovided by MGI
    Official Full Name
    signal-regulatory protein alphaprovided by MGI
    Primary source
    MGI:MGI:108563
    See related
    Ensembl:ENSMUSG00000037902 AllianceGenome:MGI:108563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; Idd13.2
    Summary
    Enables protein phosphatase binding activity and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of I-kappaB phosphorylation; negative regulation of MAPK cascade; and negative regulation of cytokine production. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; phagocytosis; and positive regulation of phagocytosis. Located in plasma membrane. Is expressed in several structures, including adrenal gland; cartilage; central nervous system; genitourinary system; and retina. Orthologous to human SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 59.8), frontal lobe adult (RPKM 57.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sirpa in Genome Data Viewer
    Location:
    2 F1; 2 63.19 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129432962..129474148)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129591042..129632228)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F830045P16 gene Neighboring gene predicted gene 14040 Neighboring gene STARR-seq mESC enhancer starr_05673 Neighboring gene predicted gene 14041 Neighboring gene STARR-seq mESC enhancer starr_05675 Neighboring gene STARR-seq mESC enhancer starr_05676 Neighboring gene STARR-seq mESC enhancer starr_05677 Neighboring gene prodynorphin Neighboring gene STARR-seq mESC enhancer starr_05678 Neighboring gene STARR-seq mESC enhancer starr_05679 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cell-cell adhesion mediator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding involved in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein phosphorylated amino acid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-12 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in granulocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monocyte extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macrophage inflammatory protein 1 alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis, recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type substrate 1
    Names
    CD172 antigen-like family member A
    SHP substrate 1
    brain Ig-like molecule with tyrosine-based activation motifs
    brain immunological-like with tyrosine-based motifs
    inhibitory receptor SHPS-1
    mSIRP-alpha1
    myD-1 antigen
    protein tyrosine phosphatase, non-receptor type substrate 1
    signal-regulatory protein alpha-1
    sirp-alpha-1
    NP_001171118.1
    NP_001277948.1
    NP_001277949.1
    NP_001277950.1
    NP_001277951.1
    NP_001342087.1
    NP_001342089.1
    NP_001407695.1
    NP_001407696.1
    NP_001407697.1
    NP_001407698.1
    NP_001407699.1
    NP_001407700.1
    NP_001407701.1
    NP_031573.2
    XP_017172053.1
    XP_017172057.1
    XP_017172058.1
    XP_030104595.1
    XP_030104598.1
    XP_036015585.1
    XP_036015587.1
    XP_036015588.1
    XP_036015589.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177647.3NP_001171118.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001171118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (2) is shorter than isoform 3.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS50708.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      A0A0R4J1Z7
      Related
      ENSMUSP00000125004.2, ENSMUST00000160276.2
      Conserved Domains (1) summary
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    2. NM_001291019.2NP_001277948.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3). Both variants 4 and 5 encode isoform 3.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS71142.1
      UniProtKB/Swiss-Prot
      A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
      UniProtKB/TrEMBL
      Q2M4I8
      Related
      ENSMUSP00000049022.8, ENSMUST00000049262.14
      Conserved Domains (4) summary
      cd00096
      Location:3538
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    3. NM_001291020.2NP_001277949.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Both variants 4 and 5 encode isoform 3.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS71142.1
      UniProtKB/Swiss-Prot
      A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
      UniProtKB/TrEMBL
      Q2M4I8
      Related
      ENSMUSP00000124048.2, ENSMUST00000161620.8
      Conserved Domains (4) summary
      cd00096
      Location:3538
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    4. NM_001291021.2NP_001277950.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (4) that is shorter than isoform 3. Variants 6 and 10 both encode the same isoform (4).
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS71143.1
      UniProtKB/TrEMBL
      E9QPT7
      Related
      ENSMUSP00000096713.4, ENSMUST00000099113.10
      Conserved Domains (1) summary
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    5. NM_001291022.2NP_001277951.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region and two in-frame exons in the central coding region, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (5) is shorter than isoform 3.
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS79845.1
      UniProtKB/TrEMBL
      E0CX65
      Related
      ENSMUSP00000124888.2, ENSMUST00000163034.8
    6. NM_001355158.2NP_001342087.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) encodes isoform 1. Variants 1, 8, 11, and 12 all encode the same isoform (1).
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS16729.1
      UniProtKB/TrEMBL
      Q2M4I8, Q6P6I8
      Related
      ENSMUSP00000137611.2, ENSMUST00000179001.8
      Conserved Domains (3) summary
      cd05772
      Location:148251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    7. NM_001355160.1NP_001342089.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL808126
      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (3) summary
      cd05772
      Location:136239
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:241344
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:23134
      Ig; Immunoglobulin domain
    8. NM_001420766.1NP_001407695.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808126
      UniProtKB/Swiss-Prot
      A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
      UniProtKB/TrEMBL
      Q2M4I8
    9. NM_001420767.1NP_001407696.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808126
      UniProtKB/TrEMBL
      Q2M4I8, Q6P6I8
      Related
      ENSMUSP00000099492.2, ENSMUST00000103203.8
    10. NM_001420768.1NP_001407697.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808126
      UniProtKB/TrEMBL
      Q2M4I8, Q6P6I8
    11. NM_001420769.1NP_001407698.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808126
    12. NM_001420770.1NP_001407699.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL808126
    13. NM_001420771.1NP_001407700.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL808126
    14. NM_001420772.1NP_001407701.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL808126
    15. NM_007547.5NP_031573.2  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031573.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4, resulting in an isoform (1) that is shorter than isoform 3. Variants 1, 8, 11, and 12 all encode the same isoform (1).
      Source sequence(s)
      AL808126
      Consensus CDS
      CCDS16729.1
      UniProtKB/TrEMBL
      Q2M4I8, Q6P6I8
      Related
      ENSMUSP00000099491.4, ENSMUST00000103202.10
      Conserved Domains (3) summary
      cd05772
      Location:148251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35146
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      129432962..129474148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316564.2XP_017172053.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    2. XM_036159695.1XP_036015588.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    3. XM_017316568.2XP_017172057.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

      UniProtKB/TrEMBL
      E9QPT7
      Conserved Domains (1) summary
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    4. XM_017316569.2XP_017172058.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X6

      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      A0A0R4J1Z7
      Conserved Domains (1) summary
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    5. XM_036159694.1XP_036015587.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    6. XM_036159692.1XP_036015585.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

      UniProtKB/Swiss-Prot
      A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:3538
      Ig; Ig strand A [structural motif]
      cd05772
      Location:148250
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:253348
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    7. XM_030248735.2XP_030104595.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    8. XM_030248738.2XP_030104598.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain
    9. XM_036159696.1XP_036015589.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      Q2M4I8
      Conserved Domains (4) summary
      cd00096
      Location:2831
      Ig; Ig strand A [structural motif]
      cd05772
      Location:141243
      IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
      cd16085
      Location:246341
      IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:28139
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177646.1: Suppressed sequence

      Description
      NM_001177646.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.