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    Eed embryonic ectoderm development [ Mus musculus (house mouse) ]

    Gene ID: 13626, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eedprovided by MGI
    Official Full Name
    embryonic ectoderm developmentprovided by MGI
    Primary source
    MGI:MGI:95286
    See related
    Ensembl:ENSMUSG00000030619 AllianceGenome:MGI:95286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    lusk; l7Rn5; l(7)5Rn
    Summary
    Enables chromatin binding activity; enzyme activator activity; and methylated histone binding activity. Involved in facultative heterochromatin formation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of adaxial/abaxial pattern formation; and regulation of gene expression. Located in pronucleus and sex chromatin. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including branchial arch; central nervous system; early embryo; embryo mesenchyme; and genitourinary system. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.5), liver E14 (RPKM 11.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eed in Genome Data Viewer
    Location:
    7 D3; 7 50.42 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89603862..89630184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89954654..89980976, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 81 Neighboring gene heat shock protein nuclear import factor Neighboring gene STARR-positive B cell enhancer ABC_E2241 Neighboring gene STARR-seq mESC enhancer starr_19498 Neighboring gene STARR-seq mESC enhancer starr_19499 Neighboring gene STARR-seq mESC enhancer starr_19500 Neighboring gene STARR-positive B cell enhancer ABC_E4947 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:97129229-97129338 Neighboring gene Eed upstream regulatory region Neighboring gene STARR-seq mESC enhancer starr_19501 Neighboring gene STARR-seq mESC enhancer starr_19504 Neighboring gene RIKEN cDNA E230029C05 gene Neighboring gene predicted gene, 32164 Neighboring gene basic transcription factor 3, pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sphingomyelin phosphodiesterase activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in facultative heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within genomic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of amide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of adaxial/abaxial pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of membrane lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sex chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polycomb protein EED
    Names
    lethal, Chr 7, Rinchik 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021876.3NP_068676.1  polycomb protein EED

      See identical proteins and their annotated locations for NP_068676.1

      Status: VALIDATED

      Source sequence(s)
      AK131976, BQ899891, CJ200028, U97675
      Consensus CDS
      CCDS40016.1
      UniProtKB/Swiss-Prot
      P97462, Q921E6
      UniProtKB/TrEMBL
      A0A5F8MPX8
      Related
      ENSMUSP00000159149.2, ENSMUST00000238981.2
      Conserved Domains (2) summary
      sd00039
      Location:96140
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:150438
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      89603862..89630184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)