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    Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19200, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pstpip1provided by MGI
    Official Full Name
    proline-serine-threonine phosphatase-interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1321396
    See related
    Ensembl:ENSMUSG00000032322 AllianceGenome:MGI:1321396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    def-2; CD2BP1
    Summary
    Enables actin binding activity and protein phosphatase binding activity. Predicted to be involved in actin filament polymerization. Located in actomyosin contractile ring; cleavage furrow; and stress fiber. Is expressed in several structures, including genitourinary system; liver; musculature; pancreas; and spleen. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 36.1), spleen adult (RPKM 16.1) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pstpip1 in Genome Data Viewer
    Location:
    9 B; 9 30.13 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55985729..56036174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56078445..56128890)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24198 Neighboring gene STARR-positive B cell enhancer mm9_chr9:55889495-55889796 Neighboring gene ring finger protein 19A pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:55923089-55923390 Neighboring gene reticulocalbin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55937639-55937826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55938770-55938923 Neighboring gene STARR-positive B cell enhancer ABC_E10547 Neighboring gene STARR-seq mESC enhancer starr_24202 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55994441-55994594 Neighboring gene STARR-positive B cell enhancer ABC_E6737 Neighboring gene tetraspanin 3 Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56112222-56112523 Neighboring gene pseudopodium-enriched atypical kinase 1, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cytokinesis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in uropod IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proline-serine-threonine phosphatase-interacting protein 1
    Names
    PEST phosphatase-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409150.1NP_001396079.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    2. NM_001409151.1NP_001396080.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    3. NM_001409152.1NP_001396081.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    4. NM_001409153.1NP_001396082.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    5. NM_001409154.1NP_001396083.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    6. NM_001409155.1NP_001396084.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    7. NM_001409156.1NP_001396085.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    8. NM_001409157.1NP_001396086.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    9. NM_001409158.1NP_001396087.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC158999
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
    10. NM_001409159.1NP_001396088.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158999
    11. NM_001409160.1NP_001396089.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158999
    12. NM_001409161.1NP_001396090.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158999
    13. NM_011193.3NP_035323.2  proline-serine-threonine phosphatase-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_035323.2

      Status: VALIDATED

      Source sequence(s)
      AC158999
      Consensus CDS
      CCDS40645.1
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
      UniProtKB/TrEMBL
      A0A0R4J0P5
      Related
      ENSMUSP00000055823.8, ENSMUST00000059206.8
      Conserved Domains (2) summary
      cd11824
      Location:362414
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cl12013
      Location:16257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55985729..56036174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242677.3XP_011240979.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X3

      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
      Conserved Domains (2) summary
      cd11824
      Location:351403
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cl12013
      Location:5246
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006510865.3XP_006510928.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
      Conserved Domains (2) summary
      cd07671
      Location:35276
      F-BAR_PSTPIP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cd11824
      Location:381433
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1

    RNA

    1. XR_004935348.1 RNA Sequence