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    Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 26876, updated on 27-Nov-2024

    Summary

    Official Symbol
    Adh4provided by MGI
    Official Full Name
    alcohol dehydrogenase 4 (class II), pi polypeptideprovided by MGI
    Primary source
    MGI:MGI:1349472
    See related
    Ensembl:ENSMUSG00000037797 AllianceGenome:MGI:1349472
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adh2
    Summary
    Enables NADPH:quinone reductase activity; alcohol dehydrogenase (NAD+) activity; and aldose reductase (NADPH) activity. Involved in fatty acid omega-oxidation. Acts upstream of or within several processes, including alcohol catabolic process; ethanol metabolic process; and quinone metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adrenal cortex; genitourinary system; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 28.8), testis adult (RPKM 3.3) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Adh4 in Genome Data Viewer
    Location:
    3 G3; 3 64.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138121217..138138444)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138415456..138432683)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23467 Neighboring gene alcohol dehydrogenase 6B (class V) Neighboring gene alcohol dehydrogenase 6 (class V), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_09107 Neighboring gene STARR-seq mESC enhancer starr_09108 Neighboring gene STARR-positive B cell enhancer ABC_E6139 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene methionyl aminopeptidase 1 Neighboring gene predicted gene, 32553

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADPH:quinone reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alcohol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables all-trans retinal binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables all-trans retinal binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables all-trans-retinol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables benzaldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables benzaldehyde dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within alcohol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in alcohol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within aldehyde metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in aldehyde metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ethanol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid omega-oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid omega-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in formaldehyde catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within quinone metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    all-trans-retinol dehydrogenase [NAD(+)] ADH4
    Names
    alcohol dehydrogenase 2
    alcohol dehydrogenase II
    alcohol dehydrogenase class II
    class II type ADH
    NP_036126.2
    XP_030108487.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011996.2NP_036126.2  all-trans-retinol dehydrogenase [NAD(+)] ADH4

      Status: PROVISIONAL

      Source sequence(s)
      AK132994
      Consensus CDS
      CCDS38653.1
      UniProtKB/Swiss-Prot
      Q3V0P5, Q9QYY9
      UniProtKB/TrEMBL
      Q496S1
      Related
      ENSMUSP00000013458.9, ENSMUST00000013458.9
      Conserved Domains (1) summary
      cd08299
      Location:3377
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      138121217..138138444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252627.1XP_030108487.1  all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform X1

      UniProtKB/TrEMBL
      Q496S1
      Conserved Domains (1) summary
      cd08299
      Location:18389
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases