dmsA dimethyl sulfoxide reductase subunit A [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: dmsA
Official Full Name: dimethyl sulfoxide reductase subunit A
Primary source: ECOCYC:EG10232
Locus tag: b0894
See related: ASAP:ABE-0003044
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0885
Summary: Verified Tat substrate: [More information is available at EcoGene: EG10232]. This subunit contains the active site and the molybdenum cofactor . [More information is available at EcoCyc: EG10232].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Data suggest that a portion of the hydrophobic region of the DmsA leader peptide determines the specificity of binding and may produce helical properties upon binding to chaperone protein DmsD (twin-arginine leader-binding protein).
Title: The hydrophobic region of the DmsA twin-arginine leader peptide determines specificity with chaperone DmsD.
established an additional role for the cluster in directing molybdenum cofactor assembly during enzyme maturation
Title: Correct assembly of iron-sulfur cluster FS0 into Escherichia coli dimethyl sulfoxide reductase (DmsABC) is a prerequisite for molybdenum cofactor insertion.
N-terminus verified by Edman degradation on mature peptide
Title: Nucleotide sequence of the dmsABC operon encoding the anaerobic dimethylsulphoxide reductase of Escherichia coli.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 4 iron, 4 sulfur cluster binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables dimethyl sulfoxide reductase activity	EXP Inferred from Experiment more info	PubMed
enables dimethyl sulfoxide reductase activity	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molybdenum ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables molybdenum ion binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin cofactor binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anaerobic electron transport chain	IDA Inferred from Direct Assay more info	PubMed
involved_in anaerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anaerobic respiration	IEP Inferred from Expression Pattern more info	PubMed
involved_in dimethyl sulfoxide metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of dimethyl sulfoxide reductase complex	IDA Inferred from Direct Assay more info	PubMed
part_of dimethyl sulfoxide reductase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in outer membrane-bounded periplasmic space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_415414.4

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