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    Man2a1 mannosidase 2, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 17158, updated on 9-Dec-2024

    Summary

    Official Symbol
    Man2a1provided by MGI
    Official Full Name
    mannosidase 2, alpha 1provided by MGI
    Primary source
    MGI:MGI:104669
    See related
    Ensembl:ENSMUSG00000024085 AllianceGenome:MGI:104669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mana2; Map-2; Mana-2
    Summary
    Enables hydrolase activity, hydrolyzing N-glycosyl compounds and mannosidase activity. Acts upstream of or within several processes, including N-glycan processing; lung alveolus development; and retina morphogenesis in camera-type eye. Located in Golgi membrane; cis-Golgi network; and extracellular space. Is expressed in adrenal gland; gland; meninges; and white fat. Used to study congenital dyserythropoietic anemia and systemic lupus erythematosus. Orthologous to human MAN2A1 (mannosidase alpha class 2A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 18.4), limb E14.5 (RPKM 11.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Man2a1 in Genome Data Viewer
    Location:
    17 E1.1; 17 33.76 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (64907683..65062105)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (64600688..64755110)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene microRNA 6420 Neighboring gene STARR-seq mESC enhancer starr_42991 Neighboring gene expressed sequence AU016765 Neighboring gene predicted gene, 35098 Neighboring gene STARR-positive B cell enhancer mm9_chr17:65017795-65018096 Neighboring gene STARR-positive B cell enhancer ABC_E11649 Neighboring gene STARR-positive B cell enhancer ABC_E2498 Neighboring gene STARR-seq mESC enhancer starr_42996 Neighboring gene down-regulated in hepatocellular carcinoma Neighboring gene RIKEN cDNA 4930583I09 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity, hydrolyzing N-glycosyl compounds IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mannosidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi medial cisterna IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-mannosidase 2
    Names
    AMan II
    golgi alpha-mannosidase II
    man II
    mannosidase alpha class 2A member 1
    mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
    NP_032575.2
    XP_030105382.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008549.2NP_032575.2  alpha-mannosidase 2

      See identical proteins and their annotated locations for NP_032575.2

      Status: VALIDATED

      Source sequence(s)
      AI461855, AK081775, AK144763, BC138371, BC138372
      Consensus CDS
      CCDS28938.1
      UniProtKB/Swiss-Prot
      B9EHS6, P27046
      Related
      ENSMUSP00000083928.4, ENSMUST00000086723.10
      Conserved Domains (1) summary
      PLN02701
      Location:1271148
      PLN02701; alpha-mannosidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      64907683..65062105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249522.2XP_030105382.1  alpha-mannosidase 2 isoform X1

      Conserved Domains (1) summary
      PLN02701
      Location:1898
      PLN02701; alpha-mannosidase