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    Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [ Mus musculus (house mouse) ]

    Gene ID: 56692, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lamtor3provided by MGI
    Official Full Name
    late endosomal/lysosomal adaptor, MAPK and MTOR activator 3provided by MGI
    Primary source
    MGI:MGI:1929467
    See related
    Ensembl:ENSMUSG00000091512 AllianceGenome:MGI:1929467
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mp1; Mapbp; Mapksp1; Map2k1ip1
    Summary
    Enables kinase activator activity. Acts upstream of or within positive regulation of MAPK cascade and protein localization to cell junction. Located in late endosome. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 27.6), placenta adult (RPKM 23.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lamtor3 in Genome Data Viewer
    Location:
    3 G3; 3 63.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137624316..137634523)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137918555..137928762)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09095 Neighboring gene DnaJ heat shock protein family (Hsp40) member B14 Neighboring gene predicted gene, 40155 Neighboring gene STARR-positive B cell enhancer ABC_E9081 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Neighboring gene STARR-positive B cell enhancer ABC_E9226 Neighboring gene predicted gene, 19708 Neighboring gene STARR-seq mESC enhancer starr_09102 Neighboring gene STARR-positive B cell enhancer ABC_E6138 Neighboring gene STARR-positive B cell enhancer ABC_E3472 Neighboring gene STARR-positive B cell enhancer ABC_E1268 Neighboring gene STARR-positive B cell enhancer mm9_chr3:137680066-137680366 Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene predicted gene 5105

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103121

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in TORC1 signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to amino acid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein localization to cell junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP IEA
    Inferred from Electronic Annotation
    more info
     
    part_of FNIP-folliculin RagC/D GAP ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Ragulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Ragulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Ragulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in late endosome IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in late endosome membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ragulator complex protein LAMTOR3
    Names
    MAPK scaffold protein 1
    MEK binding partner 1
    late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
    mitogen activated protein, binding protein
    mitogen-activated protein kinase kinase 1-interacting protein 1
    mitogen-activated protein kinase scaffold protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019920.2NP_064304.1  ragulator complex protein LAMTOR3

      See identical proteins and their annotated locations for NP_064304.1

      Status: PROVISIONAL

      Source sequence(s)
      AC146607
      Consensus CDS
      CCDS51078.1
      UniProtKB/Swiss-Prot
      O88653
      UniProtKB/TrEMBL
      Q3TX23, Q542I7
      Related
      ENSMUSP00000130811.2, ENSMUST00000168345.6
      Conserved Domains (1) summary
      pfam08923
      Location:3121
      MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137624316..137634523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)