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    Lgals2 lectin, galactose-binding, soluble 2 [ Mus musculus (house mouse) ]

    Gene ID: 107753, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lgals2provided by MGI
    Official Full Name
    lectin, galactose-binding, soluble 2provided by MGI
    Primary source
    MGI:MGI:895068
    See related
    Ensembl:ENSMUSG00000043501 AllianceGenome:MGI:895068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2200008F12Rik
    Summary
    Predicted to enable carbohydrate binding activity and galactoside binding activity. Involved in positive regulation of inflammatory response. Predicted to be part of galectin complex. Is expressed in yolk sac endoderm. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human LGALS2 (galectin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 1476.0), duodenum adult (RPKM 691.2) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lgals2 in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78735060..78739729, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78850860..78855529, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 10 Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene CDC42 effector protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E11598 Neighboring gene predicted gene, 26634 Neighboring gene STARR-positive B cell enhancer ABC_E7386 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1 Neighboring gene microRNA 6955

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables galactoside binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of galectin complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025622.3NP_079898.2  galectin-2

      See identical proteins and their annotated locations for NP_079898.2

      Status: VALIDATED

      Source sequence(s)
      AK008636, AW456488
      Consensus CDS
      CCDS37135.1
      UniProtKB/Swiss-Prot
      Q9CQW5, Q9D800, Q9D862
      UniProtKB/TrEMBL
      Q8K1I1
      Related
      ENSMUSP00000036598.5, ENSMUST00000044584.6
      Conserved Domains (1) summary
      smart00276
      Location:11130
      GLECT; Galectin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78735060..78739729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)