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    Hddc2 HD domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 69692, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hddc2provided by MGI
    Official Full Name
    HD domain containing 2provided by MGI
    Primary source
    MGI:MGI:1916942
    See related
    Ensembl:ENSMUSG00000000295 AllianceGenome:MGI:1916942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310057G13Rik
    Summary
    Predicted to enable 5'-deoxynucleotidase activity. Located in mitochondrion. Is expressed in heart. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.8), ovary adult (RPKM 2.2) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hddc2 in Genome Data Viewer
    Location:
    10 A4; 10 17.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31189296..31204200)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31313330..31328204)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26212 Neighboring gene VISTA enhancer mm762 Neighboring gene spermine synthase pseudogene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26213 Neighboring gene STARR-positive B cell enhancer ABC_E8329 Neighboring gene tumor protein D52-like 1 Neighboring gene SPT4B, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_26215 Neighboring gene predicted gene, 51764

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129436, MGC129437

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-deoxynucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 5'-deoxynucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    5'-deoxynucleotidase HDDC2
    Names
    HD domain-containing protein 2
    NP_001403988.1
    NP_001403989.1
    NP_001403990.1
    NP_001403991.1
    NP_081444.1
    XP_030101112.1
    XP_036011879.1
    XP_036011880.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417059.1NP_001403988.1  5'-deoxynucleotidase HDDC2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153969
    2. NM_001417060.1NP_001403989.1  5'-deoxynucleotidase HDDC2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153969
    3. NM_001417061.1NP_001403990.1  5'-deoxynucleotidase HDDC2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153969
    4. NM_001417062.1NP_001403991.1  5'-deoxynucleotidase HDDC2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153969
    5. NM_027168.2NP_081444.1  5'-deoxynucleotidase HDDC2 isoform 1

      See identical proteins and their annotated locations for NP_081444.1

      Status: PROVISIONAL

      Source sequence(s)
      BC104361
      Consensus CDS
      CCDS23767.1
      UniProtKB/Swiss-Prot
      Q3SXD3, Q9CV20
      Related
      ENSMUSP00000000304.7, ENSMUST00000000304.14
      Conserved Domains (1) summary
      pfam13023
      Location:19175
      HD_3; HD domain

    RNA

    1. NR_184417.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153969
    2. NR_184418.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153969
      Related
      ENSMUST00000159194.3
    3. NR_184419.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153969

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      31189296..31204200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155987.1XP_036011880.1  5'-deoxynucleotidase HDDC2 isoform X4

      Conserved Domains (1) summary
      cl21469
      Location:2393
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    2. XM_030245252.1XP_030101112.1  5'-deoxynucleotidase HDDC2 isoform X2

      Conserved Domains (1) summary
      pfam13023
      Location:110210
      HD_3; HD domain
    3. XM_036155986.1XP_036011879.1  5'-deoxynucleotidase HDDC2 isoform X3

      Conserved Domains (1) summary
      cl21469
      Location:110177
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif