U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sad succinate semialdehyde dehydrogenase (NAD(P)(+)) Sad [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947440, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sad
    Official Full Name
    succinate semialdehyde dehydrogenase (NAD(P)(+)) Sad
    Primary source
    ECOCYC:G6811
    Locus tag
    b1525
    See related
    ASAP:ABE-0005092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1518; yneI
    Summary
    Induced by exogenous succinate semialdehyde. [More information is available at EcoGene: EG13817]. Escherichia coli K-12 encodes two succinate semialdehyde dehydrogenases which differ in their ability to utilize NAD+ and NADP+. [More information is available at EcoCyc: G6811].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1613315..1614703, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative diguanylate cyclase DgcF Neighboring gene DUF4186 domain-containing protein YneG Neighboring gene glutaminase 2 Neighboring gene putative DNA-binding transcriptional regulator YneJ Neighboring gene protein YneK

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli. Fuhrer T, et al. J Bacteriol, 2007 Nov. PMID 17873044, Free PMC Article
    2. An Escherichia coli mutant defective in the NAD-dependent succinate semialdehyde dehydrogenase. Skinner MA, et al. Arch Microbiol, 1982 Sep. PMID 6756331
    3. Cloning and expression of the Escherichia coli K-12 sad gene. Marek LE, et al. J Bacteriol, 1988 Feb. PMID 3276667, Free PMC Article
    4. Predicting genes for orphan metabolic activities using phylogenetic profiles. Chen L, et al. Genome Biol, 2006. PMID 16507154, Free PMC Article
    5. Succinic semialdehyde dehydrogenases of Escherichia coli: their role in the degradation of p-hydroxyphenylacetate and gamma-aminobutyrate. Donnelly MI, et al. Eur J Biochem, 1981 Jan. PMID 7011797

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The gene is induced by succinate semialdehyde, and expression data indicate that yneI plays a unique physiological role in the general nitrogen metabolism of E. coli.
      Title: Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within arginine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular detoxification of nitrogen compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid catabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within gamma-aminobutyric acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within putrescine catabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within putrescine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    succinate semialdehyde dehydrogenase (NAD(P)(+)) Sad
    NP_416042.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1613315..1614703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416042.2 succinate semialdehyde dehydrogenase (NAD(P)(+)) Sad [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416042.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X1T4, A0A377DTJ9
      Conserved Domains (1) summary
      PRK13968
      Location:1 → 462
      PRK13968; putative succinate semialdehyde dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.