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    Syn2 synapsin II [ Mus musculus (house mouse) ]

    Gene ID: 20965, updated on 9-Dec-2024

    Summary

    Official Symbol
    Syn2provided by MGI
    Official Full Name
    synapsin IIprovided by MGI
    Primary source
    MGI:MGI:103020
    See related
    Ensembl:ENSMUSG00000009394 AllianceGenome:MGI:103020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900074L19Rik
    Summary
    Enables identical protein binding activity. Involved in calcium-ion regulated exocytosis and synaptic vesicle clustering. Acts upstream of or within neurotransmitter secretion. Located in plasma membrane; postsynaptic density; and synaptic vesicle membrane. Part of SNARE complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; intercostal muscle; and nerve. Used to study autism spectrum disorder and epilepsy. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 55.8), cortex adult (RPKM 52.0) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Syn2 in Genome Data Viewer
    Location:
    6 E3; 6 53.2 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115111863..115259587)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115134902..115282626)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36190 Neighboring gene predicted gene, 17733 Neighboring gene transcriptional adaptor 1 pseudogene Neighboring gene tissue inhibitor of metalloproteinase 4 Neighboring gene predicted gene, 38877 Neighboring gene predicted gene, 38878

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle clustering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in extrinsic component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111015.1NP_001104485.1  synapsin-2 isoform IIa

      See identical proteins and their annotated locations for NP_001104485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (IIa) encodes the longer isoform (IIa).
      Source sequence(s)
      AC147047, AC153907, BC066004, BY705489
      Consensus CDS
      CCDS51874.1
      UniProtKB/Swiss-Prot
      Q64332, Q6NZR0, Q9QWV7
      Related
      ENSMUSP00000009538.6, ENSMUST00000009538.12
      Conserved Domains (3) summary
      pfam02078
      Location:116213
      Synapsin; Synapsin, N-terminal domain
      pfam02750
      Location:215417
      Synapsin_C; Synapsin, ATP binding domain
      pfam10581
      Location:230
      Synapsin_N; Synapsin N-terminal
    2. NM_001326560.1NP_001313489.1  synapsin-2 isoform IIc

      Status: VALIDATED

      Description
      Transcript Variant: This variant (IIc) differs in the 5' and 3' UTRs and has multiple coding region differences, including an alternate start codon and novel 3' coding region, compared to variant 1. It encodes isoform IIc which is shorter and has distinct N- and C-termini, compared to isoform IIa.
      Source sequence(s)
      AK013810, AK029181, AV342495, BY772774, CX207371
      UniProtKB/TrEMBL
      Q8CE19
      Related
      ENSMUST00000204617.3
      Conserved Domains (2) summary
      pfam02078
      Location:147
      Synapsin; Synapsin, N-terminal domain
      pfam02750
      Location:49251
      Synapsin_C; Synapsin, ATP binding domain
    3. NM_013681.3NP_038709.1  synapsin-2 isoform IIb

      See identical proteins and their annotated locations for NP_038709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (IIb) lacks two exons and its 3' terminal exon extends past a splice site that is used in variant IIa. This results in a novel 3' coding region and 3' UTR, compared to variant IIa. It encodes isoform IIb which is shorter and has a distinct C-terminus, compared to isoform IIa.
      Source sequence(s)
      AC147047, AK013810, AK029181, AV342495, BC066004, BM114311, BM951908, BY705489, CX207371
      Consensus CDS
      CCDS51875.1
      UniProtKB/Swiss-Prot
      Q64332
      UniProtKB/TrEMBL
      Q8CE19
      Related
      ENSMUSP00000133121.2, ENSMUST00000169345.4
      Conserved Domains (3) summary
      pfam02078
      Location:116213
      Synapsin; Synapsin, N-terminal domain
      pfam02750
      Location:215417
      Synapsin_C; Synapsin, ATP binding domain
      pfam10581
      Location:230
      Synapsin_N; Synapsin N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      115111863..115259587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)