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    Bag2 BCL2-associated athanogene 2 [ Mus musculus (house mouse) ]

    Gene ID: 213539, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bag2provided by MGI
    Official Full Name
    BCL2-associated athanogene 2provided by MGI
    Primary source
    MGI:MGI:1891254
    See related
    Ensembl:ENSMUSG00000042215 AllianceGenome:MGI:1891254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610042A13Rik
    Summary
    Enables heat shock protein binding activity and tau protein binding activity. Involved in negative regulation of protein ubiquitination and positive regulation of proteasomal protein catabolic process. Located in axon and dendrite. Colocalizes with dendritic microtubule. Orthologous to human BAG2 (BAG cochaperone 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 26.9), placenta adult (RPKM 26.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bag2 in Genome Data Viewer
    Location:
    1 B; 1 12.81 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33784565..33796831, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33745484..33757750, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32229 Neighboring gene RAB23, member RAS oncogene family Neighboring gene zinc finger protein 451 Neighboring gene STARR-seq mESC enhancer starr_00543 Neighboring gene predicted gene 15455

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC36682

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with dendritic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein folding chaperone complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    BAG family molecular chaperone regulator 2
    Names
    BAG-2
    bcl-2-associated athanogene 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145392.2NP_663367.1  BAG family molecular chaperone regulator 2

      See identical proteins and their annotated locations for NP_663367.1

      Status: VALIDATED

      Source sequence(s)
      AK144720, BB144537, BY014303
      Consensus CDS
      CCDS14864.1
      UniProtKB/Swiss-Prot
      Q3UMR7, Q91YN9
      Related
      ENSMUSP00000042009.8, ENSMUST00000044691.9
      Conserved Domains (1) summary
      smart00264
      Location:109189
      BAG; BAG domains, present in regulator of Hsp70 proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      33784565..33796831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)